PMID- 857297
OWN - NLM
STAT- MEDLINE
DCOM- 19770611
LR  - 20190818
IS  - 0300-9475 (Print)
IS  - 0300-9475 (Linking)
VI  - 6
IP  - 4
DP  - 1977
TI  - Effect of preimmunization with native and methylated carrier on class-specific 
      anti-hapten and anti-carrier antibody response.
PG  - 273-9
AB  - Effects of priming with bovine serum albumin (BSA) and methylated BSA (MBSA) on 
      the primary anti-2,4-dinitrophenyl (DNP) response were studied in the chicken. A 
      new radioimmunoassay of class-specific antibodies (RIACA) was used to quantitate 
      IgM and IgG antibodies against BSA and DNP. The anti-DNP antibody response after 
      priming with BSA was dose-dependent: large doses of BSA suppressed and the 
      smallest dose augmented it. In contrast, no dose dependence was observed between 
      MBSA and the anti-hapten response. All doses of MBSA enhanced the primary 
      anti-DNP antibody response of both immunoglobulin classes. No corresponding 
      differences in anti-BSA antibodies were observed between BSA- and MBSA-primed 
      groups. This suggests that the anticarrier antibodies as such are not the agent 
      suppressing the anti-hapten response when large doses of native carrier are used 
      for priming. A more probable explanation of this phenomenon is a competition 
      between carrier-specific B cells and hapten-specific B cells for common T cells. 
      A less obvious explanation is the generation of more helper cells or less 
      suppressor cells when priming with MBSA than with BSA.
FAU - Viljanen, M K
AU  - Viljanen MK
FAU - Nurmi, T
AU  - Nurmi T
LA  - eng
PT  - Journal Article
PL  - England
TA  - Scand J Immunol
JT  - Scandinavian journal of immunology
JID - 0323767
RN  - 0 (Carrier Proteins)
RN  - 0 (Dinitrophenols)
RN  - 0 (Haptens)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
RN  - 27432CM55Q (Serum Albumin, Bovine)
SB  - IM
MH  - Animals
MH  - *Antibody Formation
MH  - Antibody Specificity
MH  - Carrier Proteins/*immunology
MH  - Chickens
MH  - Dinitrophenols/immunology
MH  - *Haptens
MH  - Immunization
MH  - Immunoglobulin G/analysis
MH  - Immunoglobulin M/analysis
MH  - Methylation
MH  - Serum Albumin, Bovine/pharmacology
EDAT- 1977/01/01 00:00
MHDA- 1977/01/01 00:01
CRDT- 1977/01/01 00:00
PHST- 1977/01/01 00:00 [pubmed]
PHST- 1977/01/01 00:01 [medline]
PHST- 1977/01/01 00:00 [entrez]
AID - 10.1111/j.1365-3083.1977.tb00394.x [doi]
PST - ppublish
SO  - Scand J Immunol. 1977;6(4):273-9. doi: 10.1111/j.1365-3083.1977.tb00394.x.