PMID- 8573216 OWN - NLM STAT- MEDLINE DCOM- 19960304 LR - 20141120 IS - 0004-4172 (Print) IS - 0004-4172 (Linking) VI - 45 IP - 7 DP - 1995 Jul TI - In vitro study on the interaction of Valeriana officinalis L. extracts and their amino acids on GABAA receptor in rat brain. PG - 753-5 AB - This work studied in vitro the interaction of aqueous and hydroalcoholic extracts of Valeriana officinalis L. and compounds that are present in the extracts (amino acids and valerenic acid) with the GABAA (gamma-aminobutyric acid) receptor, using the [3H] muscimol binding technique to crude synaptic membranes from rat brain cortices. Both extracts displaced [3H]muscimol bound and this effect is probably due only to their amino acid content, specially GABA. This fact explains the in vitro effect of valerian extracts on GABAA receptor but not their sedative effect. FAU - Cavadas, C AU - Cavadas C AD - Laboratory of Pharmacology, Faculty of Medicine, University of Coimbra, Portugal. FAU - Araujo, I AU - Araujo I FAU - Cotrim, M D AU - Cotrim MD FAU - Amaral, T AU - Amaral T FAU - Cunha, A P AU - Cunha AP FAU - Macedo, T AU - Macedo T FAU - Ribeiro, C F AU - Ribeiro CF LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - Germany TA - Arzneimittelforschung JT - Arzneimittel-Forschung JID - 0372660 RN - 0 (Amino Acids) RN - 0 (GABA-A Receptor Antagonists) RN - 0 (Plant Extracts) RN - 2763-96-4 (Muscimol) SB - IM MH - Amino Acids/*pharmacology MH - Animals MH - Binding, Competitive/drug effects MH - Brain Chemistry/*drug effects MH - *GABA-A Receptor Antagonists MH - In Vitro Techniques MH - Muscimol/metabolism MH - Plant Extracts/chemistry/*pharmacology MH - Rats MH - Synaptic Membranes/drug effects/metabolism EDAT- 1995/07/01 00:00 MHDA- 1995/07/01 00:01 CRDT- 1995/07/01 00:00 PHST- 1995/07/01 00:00 [pubmed] PHST- 1995/07/01 00:01 [medline] PHST- 1995/07/01 00:00 [entrez] PST - ppublish SO - Arzneimittelforschung. 1995 Jul;45(7):753-5.