PMID- 8573950
OWN - NLM
STAT- MEDLINE
DCOM- 19960314
LR  - 20170214
IS  - 1060-0280 (Print)
IS  - 1060-0280 (Linking)
VI  - 29
IP  - 11
DP  - 1995 Nov
TI  - Bioelectrical impedance analysis as an assessment of diuresis in congestive heart 
      failure.
PG  - 1091-5
AB  - OBJECTIVE: To compare changes in bioimpedance parameters and calculated total 
      body water (TBW) with conventional measurements used to assess the efficacy of 
      diuretic therapy in the treatment of heart failure. SETTING: A Veterans Affairs 
      tertiary care, teaching hospital. SUBJECTS: Twelve patients with New York Heart 
      Association (NYHA) class III congestive heart failure (CHF). DESIGN: Prospective, 
      consecutive sample, cohort, open label. INTERVENTIONS: Parenterally administered 
      furosemide; clinically dictated, outcome-oriented, adjunctive therapy of CHF. 
      OUTCOMES: Bioelectrical impedance analysis (BIA) parameters, measured volume of 
      diuresis and changes in body weight, defined clinical endpoints (NYHA criteria). 
      RESULTS: Three days of diuretic therapy with furosemide (oral and/or intravenous) 
      for CHF was associated with a measured weight loss of 4.1 +/- 0.6 kg and 
      statistically significant increases in resistance and reactance of 20.8% +/- 2.7% 
      and 22.7% +/- 6.1%, respectively (p < 0.005). Calculated TBW using BIA parameters 
      and standard equations decreased on average by 6.1 +/- 0.6 L or 11.2% +/- 1.1% (p 
      < 0.001). A significant inverse correlation was observed between change in 
      measured body weight and total body reactance (p = 0.02). CONCLUSIONS: 
      Single-frequency BIA appears to have limited clinical usefulness as a method of 
      assessing diuretic therapy in the management of CHF. Its greatest usefulness 
      appears to lie in the assessment of serial changes in individual patients and 
      patient populations that are physiologically or metabolically homogeneous. 
      Further studies are needed to establish the validity of BIA in patients with 
      decompensated CHF.
FAU - Coodley, E L
AU  - Coodley EL
AD  - Department of Medicine, University of California, Irvine, USA.
FAU - Segal, J L
AU  - Segal JL
FAU - Smith, D H
AU  - Smith DH
FAU - Neutel, J M
AU  - Neutel JM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Ann Pharmacother
JT  - The Annals of pharmacotherapy
JID - 9203131
RN  - 0 (Diuretics)
RN  - 7LXU5N7ZO5 (Furosemide)
SB  - IM
MH  - Administration, Oral
MH  - Aged
MH  - *Body Composition
MH  - Body Water/drug effects
MH  - Body Weight/drug effects
MH  - Cohort Studies
MH  - Diuretics/administration & dosage/*therapeutic use
MH  - *Electric Impedance
MH  - Female
MH  - Furosemide/administration & dosage/*therapeutic use
MH  - Heart Failure/*drug therapy
MH  - Hospitals, Teaching
MH  - Humans
MH  - Infusions, Parenteral
MH  - Male
MH  - Prospective Studies
MH  - Weight Loss/drug effects
EDAT- 1995/11/01 00:00
MHDA- 1995/11/01 00:01
CRDT- 1995/11/01 00:00
PHST- 1995/11/01 00:00 [pubmed]
PHST- 1995/11/01 00:01 [medline]
PHST- 1995/11/01 00:00 [entrez]
AID - 10.1177/106002809502901103 [doi]
PST - ppublish
SO  - Ann Pharmacother. 1995 Nov;29(11):1091-5. doi: 10.1177/106002809502901103.