PMID- 8574142
OWN - NLM
STAT- MEDLINE
DCOM- 19960308
LR  - 20211203
IS  - 0145-5680 (Print)
IS  - 0145-5680 (Linking)
VI  - 41 Suppl 1
DP  - 1995
TI  - Molecular phylogeny and dissemination of human T-cell lymphotropic virus type I 
      viewed within the context of primate evolution and human migration.
PG  - S145-61
AB  - A renewed interest in the emergence and evolution of the primate T-cell 
      lymphotropic viruses has followed the discovery of genetically distinct variants 
      of human T-cell lymphotropic virus type I (HTLV-I) in Melanesia and Australia. 
      Phylogenetic trees based on selected regions of the gag, pol, env and pX genes of 
      HTLV-I from widely separated geographic regions and of simian T-cell lymphotropic 
      virus type I (STLV-I) from African and Asian catarrhines, constructed using the 
      neighbor-joining and maximum parsimony methods, indicated that the 
      Australo-Melanesian and cosmopolitan strains of HTLV-I have evolved along 
      separate geographically dependent lineages, with African STLV-I strains 
      clustering with cosmopolitan HTLV-I strains and Asian STLV-I strains diverging 
      from the common ancestral virus before the Australo-Melanesian HTLV-I strains. 
      When viewed within the context of non-human primate evolution and human 
      occupation of Australia and Melanesia, the rate of molecular change of HTLV-I and 
      STLV-I is approximately 2.5-6.8 x 10(-7) substitutions per site per year. 
      Overall, the sequence and phylogenetic analyses are in accord with interspecies 
      virus transmission among non-human primates, as well as between non-human 
      primates and humans, with independent evolution of HTLV-I in Southeast Asia and 
      in Africa, and with dissemination of HTLV-I by forced or voluntary movements of 
      human populations. The immunosuppressive and T-cell activation properties of 
      HTLV-I places at added risk these Australian Aboriginal and Melanesian 
      populations, some of which are in imminent threat of infection with human 
      immunodeficiency virus type 1.
FAU - Yanagihara, R
AU  - Yanagihara R
AD  - Laboratory of Central Nervous System Studies, National Institute of Neurological 
      Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, 
      USA.
FAU - Saitou, N
AU  - Saitou N
FAU - Nerurkar, V R
AU  - Nerurkar VR
FAU - Song, K J
AU  - Song KJ
FAU - Bastian, I
AU  - Bastian I
FAU - Franchini, G
AU  - Franchini G
FAU - Gajdusek, D C
AU  - Gajdusek DC
LA  - eng
SI  - GENBANK/U12101
SI  - GENBANK/U12102
SI  - GENBANK/U12103
SI  - GENBANK/U12104
SI  - GENBANK/U12105
SI  - GENBANK/U12106
SI  - GENBANK/U12107
SI  - GENBANK/U12108
SI  - GENBANK/U12109
SI  - GENBANK/U12110
SI  - GENBANK/U12111
SI  - GENBANK/U12112
SI  - GENBANK/U12113
SI  - GENBANK/U12114
SI  - GENBANK/U12115
SI  - GENBANK/U12116
SI  - GENBANK/U12117
SI  - GENBANK/U12118
SI  - GENBANK/U12119
SI  - GENBANK/U12120
SI  - GENBANK/U12121
PT  - Comparative Study
PT  - Historical Article
PT  - Journal Article
PL  - France
TA  - Cell Mol Biol (Noisy-le-grand)
JT  - Cellular and molecular biology (Noisy-le-Grand, France)
JID - 9216789
RN  - 0 (DNA, Viral)
RN  - 0 (Epitopes)
RN  - 0 (Viral Structural Proteins)
SB  - IM
GS  - env
GS  - gag
GS  - pX
GS  - pol
MH  - Africa
MH  - Americas
MH  - Amino Acid Sequence
MH  - Animals
MH  - Asia, Southeastern
MH  - Australia
MH  - Base Sequence
MH  - *Biological Evolution
MH  - Cell Line
MH  - DNA, Viral/genetics
MH  - Deltaretrovirus Infections/history/veterinary/virology
MH  - *Emigration and Immigration
MH  - Epitopes/genetics
MH  - Female
MH  - Genes, Viral
MH  - HTLV-I Infections/epidemiology/history/*virology
MH  - History, 16th Century
MH  - History, 19th Century
MH  - History, 20th Century
MH  - History, Ancient
MH  - History, Medieval
MH  - Hominidae/*virology
MH  - Human T-lymphotropic virus 1/*classification/isolation & purification
MH  - Humans
MH  - Male
MH  - Melanesia
MH  - Molecular Sequence Data
MH  - Monkey Diseases/history/virology
MH  - Mutation
MH  - Phylogeny
MH  - Primates/classification/*virology
MH  - Proviruses/genetics
MH  - Racial Groups/history
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - Simian T-lymphotropic virus 1/*classification/isolation & purification
MH  - Species Specificity
MH  - Viral Structural Proteins/genetics
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
PST - ppublish
SO  - Cell Mol Biol (Noisy-le-grand). 1995;41 Suppl 1:S145-61.