PMID- 8574334
OWN - NLM
STAT- MEDLINE
DCOM- 19960312
LR  - 20190920
IS  - 0944-1174 (Print)
IS  - 0944-1174 (Linking)
VI  - 30
IP  - 5
DP  - 1995 Oct
TI  - Changes in free radical-metabolizing enzymes and lipid peroxides in the liver of 
      Long-Evans with cinnamon-like coat color rats.
PG  - 619-23
AB  - We report changes in free radical-metabolizing enzymes and the increased 
      generation of lipid peroxides associated with extreme metal accumulation in the 
      liver of the Long-Evans with cinnamon-like coat color (LEC) rat, a new mutant 
      strain displaying hereditary hepatitis and subsequent hepatocellular carcinoma. 
      The activity of free radical-metabolizing enzymes and lipid peroxides, and the 
      concentration of metal in the liver were determined sequentially after birth. 
      Mn-superoxide dismutase activity significantly increased immediately after the 
      onset of hepatitis in LEC rats, whereas no remarkable change was observed in 
      control rats. Cu, Zn-superoxide dismutase activity in LEC rats was similar to 
      that in control rats. Glutathione reductase activity increased, while glutathione 
      peroxidase activity was lower in LEC rats than in control rats throughout the 
      observation periods. Lipid peroxides, estimated by thiobarbituric acid reaction, 
      also increased 4- to 5-fold immediately after the onset of hepatitis in LEC rats. 
      Copper concentration was 30- to 50-fold higher in the liver of LEC rats than in 
      control rats, and the iron content also increased significantly before and after 
      the onset of hepatitis. These findings suggested that an oxidant injury generated 
      by toxic metals could be one of the factors responsible for hepatocellular damage 
      in this unique hereditary hepatitis.
FAU - Ohhira, M
AU  - Ohhira M
AD  - Third Department of Internal Medicine, Asahikawa Medical College, Hokkaido, 
      Japan.
FAU - Ono, M
AU  - Ono M
FAU - Ohhira, M
AU  - Ohhira M
FAU - Sekiya, C
AU  - Sekiya C
FAU - Namiki, M
AU  - Namiki M
FAU - Fujimoto, Y
AU  - Fujimoto Y
FAU - Nagao, M
AU  - Nagao M
FAU - Mori, M
AU  - Mori M
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - J Gastroenterol
JT  - Journal of gastroenterology
JID - 9430794
RN  - 0 (Lipid Peroxides)
RN  - 789U1901C5 (Copper)
RN  - E1UOL152H7 (Iron)
RN  - EC 1.- (Oxidoreductases)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Copper/metabolism
MH  - Hepatitis, Animal/*metabolism
MH  - Iron/metabolism
MH  - Lipid Peroxides/*metabolism
MH  - Male
MH  - Oxidoreductases/*metabolism
MH  - Rats
MH  - Rats, Mutant Strains
EDAT- 1995/10/01 00:00
MHDA- 1995/10/01 00:01
CRDT- 1995/10/01 00:00
PHST- 1995/10/01 00:00 [pubmed]
PHST- 1995/10/01 00:01 [medline]
PHST- 1995/10/01 00:00 [entrez]
AID - 10.1007/BF02367788 [doi]
PST - ppublish
SO  - J Gastroenterol. 1995 Oct;30(5):619-23. doi: 10.1007/BF02367788.