PMID- 8574742
OWN - NLM
STAT- MEDLINE
DCOM- 19960313
LR  - 20111117
IS  - 0954-691X (Print)
IS  - 0954-691X (Linking)
VI  - 7 Suppl 1
DP  - 1995 Aug
TI  - Immunogenetic analysis of the human leukocyte antigen DQA1 locus in patients with 
      duodenal ulcer or chronic atrophic gastritis harbouring Helicobacter pylori.
PG  - S71-3
AB  - AIM: To examine the human leukocyte antigen (HLA)-DQA1 locus in patients 
      harbouring Helicobacter pylori with chronic atrophic gastritis or duodenal ulcer 
      as part of an investigation into immunogenetic differences in the host. SUBJECTS 
      AND METHODS: We examined 116 patients harbouring H. pylori (55 patients with 
      chronic atrophic gastritis, 61 with duodenal ulcers) and 28 H. pylori-negative 
      healthy controls for HLA-DQA1 genotypes. H. pylori infection was determined by 
      culturing biopsy samples from the gastric body and antrum and by enzyme-linked 
      immunosorbent assay. HLA-DQA1 typing was carried out by the polymerase chain 
      reaction-restriction fragment length polymorphism method. RESULTS: The allele 
      frequency of DQA1*0102 was significantly higher in H. pylori-negative controls 
      (0.250) than in H. pylori-positive duodenal ulcer patients (0.090). In contrast, 
      the allele frequency of DQA1*0301 was significantly lower in H. pylori-negative 
      controls (0.214) than in H. pylori-positive duodenal ulcer patients (0.418). 
      CONCLUSION: These results suggest that there are genetic differences in the 
      HLA-DQA1 locus between H. pylori-positive duodenal ulcer patients and H. 
      pylori-negative healthy controls.
FAU - Azuma, T
AU  - Azuma T
AD  - Second Department of Internal Medicine, Fukui Medical School, Japan.
FAU - Ito, Y
AU  - Ito Y
FAU - Miyaji, H
AU  - Miyaji H
FAU - Dojyo, M
AU  - Dojyo M
FAU - Tanaka, Y
AU  - Tanaka Y
FAU - Hirai, M
AU  - Hirai M
FAU - Ito, S
AU  - Ito S
FAU - Kato, T
AU  - Kato T
FAU - Kohli, Y
AU  - Kohli Y
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur J Gastroenterol Hepatol
JT  - European journal of gastroenterology & hepatology
JID - 9000874
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQA1 antigen)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Duodenal Ulcer/genetics/*immunology/microbiology
MH  - Female
MH  - Gastritis, Atrophic/genetics/*immunology/microbiology
MH  - Genotype
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ alpha-Chains
MH  - Helicobacter Infections/complications/genetics/*immunology/microbiology
MH  - *Helicobacter pylori/isolation & purification
MH  - Humans
MH  - Male
MH  - Middle Aged
EDAT- 1995/08/01 00:00
MHDA- 1995/08/01 00:01
CRDT- 1995/08/01 00:00
PHST- 1995/08/01 00:00 [pubmed]
PHST- 1995/08/01 00:01 [medline]
PHST- 1995/08/01 00:00 [entrez]
PST - ppublish
SO  - Eur J Gastroenterol Hepatol. 1995 Aug;7 Suppl 1:S71-3.