PMID- 8575561
OWN - NLM
STAT- MEDLINE
DCOM- 19960312
LR  - 20190629
IS  - 0014-4754 (Print)
IS  - 0014-4754 (Linking)
VI  - 52
IP  - 1
DP  - 1996 Jan 16
TI  - Involvement of H1 receptors in the central antinociceptive effect of histamine: 
      pharmacological dissection by electrophysiological analysis.
PG  - 60-5
AB  - Intracerebroventricular (i.c.v.) administration of histamine (HA, 0.025-0.1 
      microM/rat) to arthritic rats induces a dose-related inhibition of the neuronal 
      thalamic firing evoked by peripheral noxious stimuli. To characterize the type(s) 
      of HA receptors involved in this depressing activity of the amine we used 
      electrophysiological techniques to examine the effects of i.c.v. administration 
      of H1 and H2 agonists and antagonists on the spontaneous and evoked nociceptive 
      firing of the thalamic neurons in rats rendered arthritic by Freund's adjuvant. 
      The H1 agonist 2-pyridylethylamine (0.4-1.0 microM/rat, i.c.v.) displayed a 
      dose-dependent antinociceptive effect very similar to that of HA, while the H2 
      agonist dimaprit (0.05-0.2 microM/rat, i.c.v.) did not modify thalamic firing. 
      Neither mepyramine (H1 antagonist, 0.1 microM/rat, i.c.v.) nor zolantidine (H2 
      antagonist, 0.01 microM/rat, i.c.v.) modified the evoked firing of rat thalamic 
      neurons. When administered before HA (0.1 microM/rat, i.c.v.) mepyramine but not 
      zolantidine was able to inhibit the antinociceptive effect of HA. On the basis of 
      the present electrophysiological results, we suggest that a specific interaction 
      of histamine with H1 receptors may be important for its antinociceptive effect on 
      afferent peripheral inputs to the thalamus.
FAU - Braga, P C
AU  - Braga PC
AD  - Department of Pharmacology, School of Medicine, University of Milan, Italy.
FAU - Soldavini, E
AU  - Soldavini E
FAU - Pecile, A
AU  - Pecile A
FAU - Sibilia, V
AU  - Sibilia V
FAU - Netti, C
AU  - Netti C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Experientia
JT  - Experientia
JID - 0376547
RN  - 0 (Receptors, Histamine)
RN  - 820484N8I3 (Histamine)
SB  - IM
MH  - Animals
MH  - Arthritis/metabolism/*physiopathology
MH  - Brain/metabolism/*physiopathology
MH  - Electrophysiology
MH  - Histamine/*administration & dosage
MH  - Male
MH  - Nociceptors/*metabolism/physiopathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Histamine/*metabolism
EDAT- 1996/01/16 00:00
MHDA- 1996/01/16 00:01
CRDT- 1996/01/16 00:00
PHST- 1996/01/16 00:00 [pubmed]
PHST- 1996/01/16 00:01 [medline]
PHST- 1996/01/16 00:00 [entrez]
AID - 10.1007/BF01922417 [doi]
PST - ppublish
SO  - Experientia. 1996 Jan 16;52(1):60-5. doi: 10.1007/BF01922417.