PMID- 8575573
OWN - NLM
STAT- MEDLINE
DCOM- 19960314
LR  - 20131121
IS  - 0903-1936 (Print)
IS  - 0903-1936 (Linking)
VI  - 8
IP  - 9
DP  - 1995 Sep
TI  - Effect of regular inhaled beclomethasone on exercise and methacholine airway 
      responses in school children with recurrent wheeze.
PG  - 1488-93
AB  - The role of airway inflammation in the pathogenesis of asthma in childhood is 
      uncertain. In the present study, 27 atopic and nonatopic children aged 7-9 yrs 
      who had > or = 5 episodes of wheeze and symptoms of exercise-induced asthma (EIA) 
      in the previous 12 months, performed a methacholine challenge and exercise test 
      on separate days at monthly intervals. The subjects had not received oral or 
      inhaled corticosteroids for 12 months prior to the study. The dose-response 
      relationship to inhaled methacholine was expressed as the cumulative dose 
      provoking a 20% decrease in forced expiratory volume in one second (PD20). Forced 
      expiratory volume in one second (FEV1) and peak expiratory flow (PEF) were 
      measured prior to the exercise test and at 0, 3, 5, 10, 15 and 20 min following 
      maximal exercise. Following the first methacholine challenge and exercise test, 
      the children were randomized in a double-blind manner to receive inhaled 
      beclomethasone dipropionate (BDP) 200 micrograms b.i.d. or a placebo b.i.d. from 
      a Diskhaler for 3 months. All children were asymptomatic at the time of testing, 
      and there was no significant change in the baseline FEV1 of any subject prior to 
      either challenge throughout the study period. When compared to placebo, the 
      bronchial responsiveness to exercise and methacholine was significantly 
      attenuated in the children who had received inhaled BDP for at least 1 month. 
      There was no relationship between the bronchial responsiveness to methacholine 
      and exercise. There was no significant difference in the bronchial responsiveness 
      to either stimulus in the atopic and nonatopic children. The results of this 
      study suggest that immunoglobulin E (IgE)- and non-IgE-mediated airway 
      inflammation are important in exercise- and methacholine-induced 
      bronchoconstriction in children with recurrent wheeze, although it is probable 
      that different mechanisms are responsible.
FAU - Freezer, N J
AU  - Freezer NJ
AD  - University Medicine, Southampton General Hospital, UK.
FAU - Croasdell, H
AU  - Croasdell H
FAU - Doull, I J
AU  - Doull IJ
FAU - Holgate, S T
AU  - Holgate ST
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
RN  - 0 (Anti-Asthmatic Agents)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Bronchoconstrictor Agents)
RN  - 0 (Glucocorticoids)
RN  - 0W5ETF9M2K (Methacholine Chloride)
RN  - KGZ1SLC28Z (Beclomethasone)
SB  - IM
MH  - Administration, Inhalation
MH  - Administration, Topical
MH  - Analysis of Variance
MH  - Anti-Asthmatic Agents/administration & dosage/*therapeutic use
MH  - Anti-Inflammatory Agents/administration & dosage/*therapeutic use
MH  - Asthma/*drug therapy/physiopathology
MH  - Asthma, Exercise-Induced/physiopathology
MH  - Beclomethasone/administration & dosage/*therapeutic use
MH  - Bronchial Provocation Tests
MH  - Bronchoconstrictor Agents/pharmacology
MH  - Child
MH  - Double-Blind Method
MH  - Exercise/*physiology
MH  - Female
MH  - Forced Expiratory Volume/drug effects
MH  - Glucocorticoids
MH  - Humans
MH  - Male
MH  - Methacholine Chloride/pharmacology
MH  - Prospective Studies
MH  - Recurrence
MH  - Respiratory Mechanics/*drug effects
MH  - Respiratory Sounds
EDAT- 1995/09/01 00:00
MHDA- 1995/09/01 00:01
CRDT- 1995/09/01 00:00
PHST- 1995/09/01 00:00 [pubmed]
PHST- 1995/09/01 00:01 [medline]
PHST- 1995/09/01 00:00 [entrez]
PST - ppublish
SO  - Eur Respir J. 1995 Sep;8(9):1488-93.