PMID- 8575577
OWN - NLM
STAT- MEDLINE
DCOM- 19960314
LR  - 20131121
IS  - 0903-1936 (Print)
IS  - 0903-1936 (Linking)
VI  - 8
IP  - 9
DP  - 1995 Sep
TI  - Allergic sensitization is associated with increased bronchial responsiveness: a 
      prospective study of allergy to laboratory animals.
PG  - 1514-9
AB  - The purpose of this prospective study was to investigate the extent of change in 
      bronchial responsiveness and the prognostic value of methacholine provocation in 
      early sensitization to laboratory animals. Thirty eight laboratory technicians 
      were studied during training (before first exposure) and after having been 
      exposed to laboratory animals for a median 18 (range 5-33) months. On both 
      occasions they were subjected to spirometry, bronchial methacholine challenge, 
      skin-prick tests and blood sampling, and responded to questionnaires. Nine (24%) 
      developed laboratory animal allergy (LAA), defined as animal work-related 
      symptoms (n = 8), or specific immunoglobulin E (IgE) (n = 7) or both. In the LAA 
      group, bronchial responsiveness was normal before employment, but had increased 
      significantly at follow-up compared to technicians who had not developed LAA. Six 
      of the nine LAA subjects had a more than threefold increase in bronchial 
      responsiveness, and three of these reported chest symptoms. Spirometric values 
      were not different between the groups prior to exposure or at follow-up, and had 
      no prognostic value. However, a pre-employment level of total IgE > 100 kU.L-1 
      predicted the development of LAA (relative risk 2.8). Thus, early LAA was 
      associated with increased bronchial responsiveness in most subjects. In contrast 
      to total IgE, the level of pre-employment bronchial responsiveness or lung 
      function did not influence the magnitude of change in responsiveness, nor predict 
      sensitization.
FAU - Renstrom, A
AU  - Renstrom A
AD  - National Institute of Occupational Health, Sweden.
FAU - Malmberg, P
AU  - Malmberg P
FAU - Larsson, K
AU  - Larsson K
FAU - Larsson, P H
AU  - Larsson PH
FAU - Sundblad, B M
AU  - Sundblad BM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
RN  - 0 (Bronchoconstrictor Agents)
RN  - 0W5ETF9M2K (Methacholine Chloride)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Animal Technicians
MH  - Animals
MH  - Animals, Laboratory/*immunology
MH  - Bronchial Hyperreactivity/etiology/*immunology
MH  - Bronchial Provocation Tests
MH  - Bronchoconstrictor Agents
MH  - Chickens
MH  - Cricetinae
MH  - Female
MH  - Horses
MH  - Humans
MH  - Immunoglobulin E/*analysis
MH  - Male
MH  - Methacholine Chloride
MH  - Mice
MH  - Occupational Diseases/etiology/*immunology
MH  - Occupational Exposure/adverse effects
MH  - Patch Tests
MH  - Prospective Studies
MH  - Rabbits
MH  - Respiratory Function Tests
MH  - Swine
EDAT- 1995/09/01 00:00
MHDA- 1995/09/01 00:01
CRDT- 1995/09/01 00:00
PHST- 1995/09/01 00:00 [pubmed]
PHST- 1995/09/01 00:01 [medline]
PHST- 1995/09/01 00:00 [entrez]
PST - ppublish
SO  - Eur Respir J. 1995 Sep;8(9):1514-9.