PMID- 8579122
OWN - NLM
STAT- MEDLINE
DCOM- 19960311
LR  - 20181113
IS  - 0002-9440 (Print)
IS  - 1525-2191 (Electronic)
IS  - 0002-9440 (Linking)
VI  - 148
IP  - 2
DP  - 1996 Feb
TI  - Chromosomal translocation t(X;18) in human synovial sarcomas analyzed by 
      fluorescence in situ hybridization using paraffin-embedded tissue.
PG  - 601-9
AB  - Synovial sarcoma is characterized cytogenetically by translocation 
      t(X;18)(p11.2;q11.2). In this study, 28 cases that had been diagnosed initially 
      as synovial sarcoma, including 2 fibrosarcomas, and 1 leiomyosarcoma were 
      collected and examined for translocation t(X;18) on paraffin-embedded tissues by 
      fluorescence in situ hybridization (FISH). Of the synovial sarcomas, 25 showed 
      findings consistent with translocation t(X;18) with an additional copy signal for 
      the total probe of X and 18 chromosomes. The other three cases, as well as the 
      two fibrosarcomas and the leiomyosarcoma, did not show this translocation. One 
      (case 26) of three negative cases was diagnosed finally as leiomyosarcoma and 
      another (case 27) as malignant peripheral nerve sheath tumor from histological 
      and immunohistochemical analysis. Thus, in all, 25 (96%) of 26 synovial sarcomas 
      showed findings consistent with translocation t(X;18). In summary, translocation 
      t(X;18) is a chromosomal aberration specific for synovial sarcoma. The 
      fluorescence in situ hybridization technique can be used even on cells from 
      paraffin-embedded tissues, and is a useful diagnostic aid for synovial sarcoma.
FAU - Nagao, K
AU  - Nagao K
AD  - Department of Pathology, Faculty of Medicine, Tottori University, Japan.
FAU - Ito, H
AU  - Ito H
FAU - Yoshida, H
AU  - Yoshida H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Pathol
JT  - The American journal of pathology
JID - 0370502
RN  - 0 (DNA Probes)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - Chromosomes, Human, Pair 18/*genetics
MH  - DNA Probes
MH  - Epithelial Cells
MH  - Female
MH  - Humans
MH  - Immunophenotyping
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Paraffin Embedding
MH  - Sarcoma, Synovial/diagnosis/*genetics/pathology
MH  - Soft Tissue Neoplasms/diagnosis/*genetics/pathology
MH  - Translocation, Genetic/*genetics
MH  - X Chromosome/*genetics
PMC - PMC1861692
EDAT- 1996/02/01 00:00
MHDA- 1996/02/01 00:01
PMCR- 1996/08/01
CRDT- 1996/02/01 00:00
PHST- 1996/02/01 00:00 [pubmed]
PHST- 1996/02/01 00:01 [medline]
PHST- 1996/02/01 00:00 [entrez]
PHST- 1996/08/01 00:00 [pmc-release]
PST - ppublish
SO  - Am J Pathol. 1996 Feb;148(2):601-9.