PMID- 8581841
OWN - NLM
STAT- MEDLINE
DCOM- 19960321
LR  - 20190830
IS  - 0954-7894 (Print)
IS  - 0954-7894 (Linking)
VI  - 25
IP  - 11
DP  - 1995 Nov
TI  - The association of age, gender and smoking with total IgE and specific IgE.
PG  - 1083-91
AB  - BACKGROUND: Smoking has been identified as a risk factor for atopy but there are 
      difficulties in interpreting many of the previous studies because the subjects 
      who have been studied have not been representative of the entire population and 
      because there is confounding between gender and smoking. OBJECTIVE: To 
      investigate the association of age, gender and smoking with total IgE and 
      specific IgE to house dust mite, grass and cat. METHODS: A stratified random 
      sample of 20-44 year olds living in three centres in East Anglia and registered 
      with a local general practitioner had blood taken for total immunoglobulin E 
      (IgE) and specific IgE. A smoking history was obtained from a structured 
      interviewer-led questionnaire. RESULTS: Among non-smokers geometric mean total 
      IgE was higher in men than women but unrelated to age. Smoking explained less 
      than 1% of the variation in total IgE. Smoking was associated with an increased 
      risk of sensitization to house dust mite (odds ratio 1.59; 95% confidence 
      interval 1.02-2.48) but a decreased risk of sensitization to grass (odds ratio 
      0.45; 95% confidence interval 0.28-0.71) and cat (odds ratio 0.47; 0.24-0.94). 
      CONCLUSION: Men aged 20-44 years have higher total IgE levels than women of the 
      same age. In young adults smoking explains little of the variation in total IgE 
      and its association with sensitization to common allergens varies between 
      allergens.
FAU - Jarvis, D
AU  - Jarvis D
AD  - Department of Public Health Medicine, United Medical School, Guys', London, UK.
FAU - Luczynska, C
AU  - Luczynska C
FAU - Chinn, S
AU  - Chinn S
FAU - Burney, P
AU  - Burney P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Exp Allergy
JT  - Clinical and experimental allergy : journal of the British Society for Allergy 
      and Clinical Immunology
JID - 8906443
RN  - 0 (Allergens)
RN  - 0 (Environmental Pollutants)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Aging/*immunology
MH  - Allergens/*immunology
MH  - Animals
MH  - *Antibody Specificity
MH  - Asthma/immunology
MH  - Cats/immunology
MH  - Environmental Pollutants/immunology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Mites/immunology
MH  - Poaceae/immunology
MH  - Random Allocation
MH  - *Sex Characteristics
MH  - Smoking/*immunology
EDAT- 1995/11/01 00:00
MHDA- 1995/11/01 00:01
CRDT- 1995/11/01 00:00
PHST- 1995/11/01 00:00 [pubmed]
PHST- 1995/11/01 00:01 [medline]
PHST- 1995/11/01 00:00 [entrez]
AID - 10.1111/j.1365-2222.1995.tb03255.x [doi]
PST - ppublish
SO  - Clin Exp Allergy. 1995 Nov;25(11):1083-91. doi: 
      10.1111/j.1365-2222.1995.tb03255.x.