PMID- 8582269
OWN - NLM
STAT- MEDLINE
DCOM- 19960319
LR  - 20220215
IS  - 0950-1991 (Print)
IS  - 0950-1991 (Linking)
VI  - 121
IP  - 11
DP  - 1995 Nov
TI  - Specificity of CNS and PNS regulatory subelements comprising pan-neural enhancers 
      of the deadpan and scratch genes is achieved by repression.
PG  - 3549-60
AB  - The Drosophila pan-neural genes deadpan (dpn) and scratch (scrt) are expressed in 
      most or all developing neural precursor cells of the central nervous system (CNS) 
      and peripheral nervous system (PNS). We have identified a cis-acting enhancer 
      element driving full pan-neural expression of the dpn gene which is composed of 
      independent CNS- and PNS-specific subelements. We have also identified CNS- and 
      PNS-specific subelements of the scrt enhancer. Deletion analysis of the dpn and 
      scrt PNS-specific subelements reveals that PNS specificity of these two 
      evolutionarily unrelated enhancers is achieved in part by repression of CNS 
      expression. We discuss the implications of the striking organizational 
      similarities of the dpn, scrt, and sna pan-neural enhancers.
FAU - Emery, J F
AU  - Emery JF
AD  - Department of Biology, University of California, San Diego, La Jolla 92093, USA.
FAU - Bier, E
AU  - Bier E
LA  - eng
GR  - R01-NS29870-01/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Development
JT  - Development (Cambridge, England)
JID - 8701744
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Snail Family Transcription Factors)
RN  - 0 (Transcription Factors)
RN  - 0 (scrt protein, Drosophila)
RN  - 0 (sna protein, Drosophila)
RN  - 149347-68-2 (Dpn protein, Drosophila)
SB  - IM
MH  - Animals
MH  - Basic Helix-Loop-Helix Transcription Factors
MH  - Central Nervous System/embryology
MH  - DNA-Binding Proteins/*genetics
MH  - Drosophila/*embryology/*genetics
MH  - *Drosophila Proteins
MH  - *Enhancer Elements, Genetic
MH  - Gene Expression
MH  - *Gene Expression Regulation, Developmental
MH  - *Genes, Insect
MH  - In Situ Hybridization
MH  - Nervous System/*embryology
MH  - Nuclear Proteins/*genetics
MH  - Peripheral Nervous System/embryology
MH  - Promoter Regions, Genetic
MH  - Snail Family Transcription Factors
MH  - Transcription Factors/*genetics
EDAT- 1995/11/01 00:00
MHDA- 1995/11/01 00:01
CRDT- 1995/11/01 00:00
PHST- 1995/11/01 00:00 [pubmed]
PHST- 1995/11/01 00:01 [medline]
PHST- 1995/11/01 00:00 [entrez]
AID - 10.1242/dev.121.11.3549 [doi]
PST - ppublish
SO  - Development. 1995 Nov;121(11):3549-60. doi: 10.1242/dev.121.11.3549.