PMID- 8584261
OWN - NLM
STAT- MEDLINE
DCOM- 19960319
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 200
IP  - 1
DP  - 1995 Nov 10
TI  - Expression of neurotrophins and their receptors in sciatic nerve of 
      experimentally diabetic rats.
PG  - 37-40
AB  - The levels of neurotrophins and their receptor mRNAs were measured in rat sciatic 
      nerve, after 6 or 12 weeks of streptozotocin-induced diabetes. Expression of 
      neurotrophin-3 (NT-3) and neurotrophin-4 (NT-4) was decreased by 50 and 29%, 
      respectively, compared with age-matched controls after 12 weeks of diabetes. 
      Expression of brain-derived neurotrophic factor (BDNF) was not detected. In 
      addition, diabetes induced a reduction in the expression levels of the 
      neurotrophin receptors: trkB mRNA decreased by 50% after 6 weeks of diabetes, but 
      returned to control levels after 12 weeks; meanwhile the trkC and p75LNGFR 
      transcripts were reduced by 20% of control at both times studied. trkA expression 
      was below detection limits. Thus, these data suggest that a reduction in 
      neurotrophin and neurotrophin receptors could contribute to the development and 
      maintenance of diabetic neuropathy.
FAU - Rodriguez-Pena, A
AU  - Rodriguez-Pena A
AD  - Instituto de Investigaciones Biomedicas (C.S.I.C.), Madrid, Spain.
FAU - Botana, M
AU  - Botana M
FAU - Gonzalez, M
AU  - Gonzalez M
FAU - Requejo, F
AU  - Requejo F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neurotrophin 3)
RN  - 0 (RNA, Messenger)
RN  - P658DCA9XD (neurotrophin 4)
SB  - IM
MH  - Animals
MH  - Diabetes Mellitus, Experimental/*metabolism
MH  - Male
MH  - Nerve Growth Factors/*metabolism
MH  - Neurotrophin 3
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Sciatic Nerve/*metabolism
MH  - Time Factors
EDAT- 1995/11/10 00:00
MHDA- 1995/11/10 00:01
CRDT- 1995/11/10 00:00
PHST- 1995/11/10 00:00 [pubmed]
PHST- 1995/11/10 00:01 [medline]
PHST- 1995/11/10 00:00 [entrez]
AID - 0304-3940(95)12067-E [pii]
AID - 10.1016/0304-3940(95)12067-e [doi]
PST - ppublish
SO  - Neurosci Lett. 1995 Nov 10;200(1):37-40. doi: 10.1016/0304-3940(95)12067-e.