PMID- 8584263
OWN - NLM
STAT- MEDLINE
DCOM- 19960319
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 200
IP  - 1
DP  - 1995 Nov 10
TI  - Brain-derived neurotrophic factor promotes survival and blocks nitric oxide 
      synthase expression in adult rat spinal motoneurons after ventral root avulsion.
PG  - 45-8
AB  - In adult spinal motoneurons, retrograde cell death is induced by ventral root 
      avulsion. A lethal effect of nitric oxide has been implicated, since nitric oxide 
      synthase (NOS) is expressed in the motoneurons destined to die. Our study 
      investigates the effects of brain-derived neurotrophic factor (BDNF) and ciliary 
      neurotrophic factor (CNTF) on the retrograde cell death and NOS expression of 
      adult rat spinal motoneurons. Following ventral root avulsion and 4 weeks of 
      continuous treatment, BDNF, but not CNTF, was found to prevent cell death and NOS 
      expression in the lesioned motoneurons. This suggests a therapeutic potential for 
      BDNF in the adult nervous system, possibly through blockage of nitric oxide 
      synthesis.
FAU - Novikov, L
AU  - Novikov L
AD  - Department of Anatomy, Umea University, Sweden.
FAU - Novikova, L
AU  - Novikova L
FAU - Kellerth, J O
AU  - Kellerth JO
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Ciliary Neurotrophic Factor)
RN  - 0 (Nerve Tissue Proteins)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor
MH  - Cell Survival
MH  - Ciliary Neurotrophic Factor
MH  - Female
MH  - Histocytochemistry
MH  - Motor Neurons/*drug effects
MH  - Nerve Tissue Proteins/*pharmacology
MH  - Nitric Oxide/pharmacology
MH  - Nitric Oxide Synthase/*drug effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Spinal Cord/*drug effects
EDAT- 1995/11/10 00:00
MHDA- 1995/11/10 00:01
CRDT- 1995/11/10 00:00
PHST- 1995/11/10 00:00 [pubmed]
PHST- 1995/11/10 00:01 [medline]
PHST- 1995/11/10 00:00 [entrez]
AID - 0304-3940(95)12078-I [pii]
AID - 10.1016/0304-3940(95)12078-i [doi]
PST - ppublish
SO  - Neurosci Lett. 1995 Nov 10;200(1):45-8. doi: 10.1016/0304-3940(95)12078-i.