PMID- 8584318
OWN - NLM
STAT- MEDLINE
DCOM- 19960321
LR  - 20190818
IS  - 0891-3668 (Print)
IS  - 0891-3668 (Linking)
VI  - 14
IP  - 10
DP  - 1995 Oct
TI  - Detection of IgM antibodies to human herpesvirus 6 in Romanian children with 
      nonprogressive human immunodeficiency virus disease.
PG  - 891-4
AB  - The prevalence of human herpesvirus 6 (HHV-6) infection and the course of human 
      immunodeficiency virus (HIV) disease were investigated in 25 Romanian children 
      with nosocomial HIV-1 infection. HHV-6 IgM and IgG antibodies were detected by 
      enzyme immunoassay (EIA) and immunofluorescence assay (IFA) at the beginning of 
      the study and after 18 months, concomitantly with collection of virologic, 
      immunologic and clinical data. The initial HHV-6 seropositivity was 92% by EIA 
      and 76% by IFA, whereas final testing showed 100% positivity by EIA and 84% by 
      IFA. Positive HHV-6 IgM antibodies were detected in 10 children (40%) by EIA and 
      IFA. Of these 9 children (36%) by EIA and 6 (24%) by IFA had both initial and 
      final IgM antibodies. Children with HHV-6 IgM antibodies had a higher prevalence 
      of pneumonitis than those without (100% vs. 53.3%; P < 0.01). In addition they 
      more frequently showed positive p24 antigen detection (67% vs. 40%) and positive 
      HIV-1 culture (80% vs. 69%). Nevertheless the patients with HHV-6 IgM antibodies 
      showed a slight increase in the final mean CD4+ T cell count (from 1.140 to 1.185 
      x 10(6)/liter), whereas those with HHV-6 IgG alone showed a statistically 
      significant (P = 0.01) decrease (from 1.395 to 968 CD4+ T-cells x 10(6)/liter). 
      Therefore current or recent HHV-6 infection, as revealed by positive HHV-6 IgM 
      antibodies, appeared to be associated with the development of pneumonitis but not 
      with progression of HIV disease. A possible competitive inhibition of HIV-1 by 
      HHV-6 or a stimulating effect of HHV-6 on CD4+ T-cell production may be 
      suggested.
FAU - Nigro, G
AU  - Nigro G
AD  - Pediatric Institute, La Sapienza University, Rome, Italy.
FAU - Luzi, G
AU  - Luzi G
FAU - Krzysztofiak, A
AU  - Krzysztofiak A
FAU - D'Orio, F
AU  - D'Orio F
FAU - Aiuti, F
AU  - Aiuti F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pediatr Infect Dis J
JT  - The Pediatric infectious disease journal
JID - 8701858
RN  - 0 (Antibodies, Viral)
RN  - 0 (HIV Antibodies)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
SB  - IM
MH  - AIDS-Related Opportunistic Infections/*diagnosis/epidemiology
MH  - Antibodies, Viral/*blood
MH  - Child, Preschool
MH  - Cross Infection
MH  - Disease Progression
MH  - Female
MH  - Fluorescent Antibody Technique, Indirect
MH  - HIV Antibodies/blood
MH  - HIV Infections/complications/immunology/*physiopathology
MH  - *HIV-1
MH  - Herpesviridae Infections/complications/*diagnosis/epidemiology
MH  - Herpesvirus 6, Human/*immunology
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Immunoglobulin G/*blood
MH  - Immunoglobulin M/*blood
MH  - Infant
MH  - Male
MH  - Prevalence
MH  - Romania/epidemiology
EDAT- 1995/10/01 00:00
MHDA- 1995/10/01 00:01
CRDT- 1995/10/01 00:00
PHST- 1995/10/01 00:00 [pubmed]
PHST- 1995/10/01 00:01 [medline]
PHST- 1995/10/01 00:00 [entrez]
AID - 10.1097/00006454-199510000-00014 [doi]
PST - ppublish
SO  - Pediatr Infect Dis J. 1995 Oct;14(10):891-4. doi: 
      10.1097/00006454-199510000-00014.