PMID- 8584971
OWN - NLM
STAT- MEDLINE
DCOM- 19960319
LR  - 20031114
IS  - 0887-4476 (Print)
IS  - 0887-4476 (Linking)
VI  - 21
IP  - 2
DP  - 1995 Oct
TI  - Plastic effect of soiled bedding on the structure of synapses in rat accessory 
      olfactory bulb.
PG  - 104-9
AB  - The effects of exposure to soiled bedding on synaptic morphology in the accessory 
      olfactory bulb (AOB) were examined in adult male rats. Forty-day-old male rats 
      were isolated. One group was exposed to bedding soiled by male and female rats 
      (EC). Another group was exposed only to male-soiled bedding (SC). A third group 
      was exposed to clean bedding (IC). After 2 months, the animals were sacrificed 
      for electron microscopy. The size and the numerical density of synapses were 
      measured in the glomerulus and the granule cell layer. In the glomerulus, the 
      mean size of the synapses was significantly greater in the EC than in the IC 
      group, whereas that in the SC group appeared to be intermediate between those in 
      the EC and the IC groups but was not significantly different from those in the EC 
      and the IC groups. There was no statistically significant difference in the 
      density of synapses among the three groups. Synapses in the granule cell layer 
      are classified into two types: 1) perforated synapses, which are characterized by 
      discontinuities in their postsynaptic thickenings, and 2) nonperforated synapses. 
      The mean size of perforated synapses was significantly greater in the EC than in 
      the IC and SC groups; however, no statistically significant difference was 
      observed in the size of nonperforated synapses among the three groups. Moreover, 
      no statistically significant difference was observed in the numerical densities 
      of either perforated or nonperforated synapses among the three groups. These 
      results suggested that exposure to a more complex soiled bedding environment 
      (i.e., to bedding soiled by both male and female rats) can induce greater 
      structural changes of the synapses in the AOB of male adult rats.
FAU - Ichikawa, M
AU  - Ichikawa M
AD  - Department of Anatomy and Embryology, Tokyo Metropolitan Institute for 
      Neuroscience, Japan.
FAU - Matsuoka, M
AU  - Matsuoka M
FAU - Mori, Y
AU  - Mori Y
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Synapse
JT  - Synapse (New York, N.Y.)
JID - 8806914
SB  - IM
MH  - Animals
MH  - Bedding and Linens
MH  - *Environment
MH  - Feces
MH  - Female
MH  - Housing, Animal
MH  - Male
MH  - Microscopy, Electron
MH  - *Neuronal Plasticity
MH  - Olfactory Bulb/cytology/*physiology/*ultrastructure
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Synapses/*physiology/*ultrastructure
MH  - Urine
EDAT- 1995/10/01 00:00
MHDA- 1995/10/01 00:01
CRDT- 1995/10/01 00:00
PHST- 1995/10/01 00:00 [pubmed]
PHST- 1995/10/01 00:01 [medline]
PHST- 1995/10/01 00:00 [entrez]
AID - 10.1002/syn.890210203 [doi]
PST - ppublish
SO  - Synapse. 1995 Oct;21(2):104-9. doi: 10.1002/syn.890210203.