PMID- 8585982
OWN - NLM
STAT- MEDLINE
DCOM- 19960322
LR  - 20131121
IS  - 0366-6999 (Print)
IS  - 0366-6999 (Linking)
VI  - 108
IP  - 11
DP  - 1995 Nov
TI  - Pentoxifylline ameliorates pulmonary damage caused by Streptococcus pneumoniae 
      infection in mouse.
PG  - 864-9
AB  - Streptococcus pneumoniae stimulated mouse peritoneal macrophage to release tumor 
      necrosis factor-alpha (TNF alpha) in vitro. When penicillin was added into the 
      medium with bacteria, TNF alpha release was accelerated. Pentoxifylline (PTX), a 
      phosphodiesterase inhibitor, significantly attenuated TNF alpha release caused 
      either by Streptococcus pneumoniae or by its lysates. In this experiment, 150 
      Kunming mice were infected with Streptococcus pneumoniae through inspiration. 
      Dynamic changes of TNF alpha concentration in serum and bronchoalveolar lavage 
      fluid were determined, and pulmonary pathological changes were also observed. It 
      was found that PTX significantly attenuated TNF alpha activity in serum and 
      bronchoalveolar lavage fluid, and inhibited white blood cell chemotaxis, 
      emigration and infiltration. In conclusion, Streptococcus pneumoniae infection 
      stimulates the release of TNF alpha which is probably the major mediater that 
      causes tissue damage during Streptococcus pneumoniae infection. The mechanism is 
      probably that Streptococcus pneumoniae and its lysates activate TNF alpha gene 
      transcription. As penicillin accelerates TNF alpha release, treatment with 
      penicillin alone may aggravate the tissue damage. Combined treatment with PTX may 
      be more reasonable.
FAU - Cui, X
AU  - Cui X
AD  - Respiratory Disease Research Laboratory, Union Hospital, Tongji Medical 
      University, Wuhan.
FAU - Zhang, R
AU  - Zhang R
FAU - Fu, W
AU  - Fu W
FAU - Cao, Z
AU  - Cao Z
LA  - eng
PT  - Journal Article
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 0 (Phosphodiesterase Inhibitors)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - SD6QCT3TSU (Pentoxifylline)
SB  - IM
MH  - Animals
MH  - Bronchoalveolar Lavage Fluid/chemistry
MH  - Mice
MH  - Pentoxifylline/*pharmacology
MH  - Phosphodiesterase Inhibitors/*pharmacology
MH  - Pneumococcal Infections/*metabolism/pathology
MH  - Pneumonia, Pneumococcal/*metabolism/pathology
MH  - Pulmonary Alveoli/*pathology
MH  - Tumor Necrosis Factor-alpha/*metabolism
EDAT- 1995/11/01 00:00
MHDA- 1995/11/01 00:01
CRDT- 1995/11/01 00:00
PHST- 1995/11/01 00:00 [pubmed]
PHST- 1995/11/01 00:01 [medline]
PHST- 1995/11/01 00:00 [entrez]
PST - ppublish
SO  - Chin Med J (Engl). 1995 Nov;108(11):864-9.