PMID- 8586006
OWN - NLM
STAT- MEDLINE
DCOM- 19960325
LR  - 20221207
IS  - 0149-5992 (Print)
IS  - 0149-5992 (Linking)
VI  - 18
IP  - 5
DP  - 1995 May
TI  - HLA-DQ beta 1 typing and non-Asp57 alleles in the aborigine population of 
      Senegal.
PG  - 677-80
AB  - OBJECTIVE: To investigate, in Senegalese subjects, the frequency of human 
      leukocyte antigen (HLA)-DQ beta 1 alleles and their role in susceptibility to 
      insulin-dependent diabetes mellitus (IDDM). RESEARCH DESIGN AND METHODS: HLA-DQ 
      beta 1 typing was done in 55 IDDM subjects and 118 nondiabetic control subjects 
      by means of polymerase chain reaction restriction fragment length polymorphism. 
      RESULTS: Alleles bearing a codon for an Asp residue at position 57 in the DQ 
      beta-chain were associated with a significantly lower risk of IDDM. Alleles 0201 
      and 0302 (Ala57) were positively associated with diabetes, but allele 0501 
      (Val57) was less frequent in IDDM subjects than in control subjects. CONCLUSIONS: 
      HLA-DQ beta 1 alleles may be genetic susceptibility markers for IDDM in the 
      Senegalese population, as they are in Caucasian populations.
FAU - Chauffert, M
AU  - Chauffert M
AD  - Laboratoire de Biochimie, Foundation Hopital Saint-Joseph, Paris, France.
FAU - Cisse, A
AU  - Cisse A
FAU - Chevenne, D
AU  - Chevenne D
FAU - Parfait, B
AU  - Parfait B
FAU - Michel, S
AU  - Michel S
FAU - Trivin, F
AU  - Trivin F
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 30KYC7MIAI (Aspartic Acid)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - *Aspartic Acid
MH  - Black People/genetics
MH  - Child
MH  - Diabetes Mellitus, Type 1/epidemiology/*genetics/immunology
MH  - Female
MH  - Gene Frequency
MH  - Genetic Carrier Screening
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - Histocompatibility Testing
MH  - Homozygote
MH  - Humans
MH  - Male
MH  - Native Hawaiian or Other Pacific Islander/*genetics
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Restriction Fragment Length
MH  - Racial Groups
MH  - Reference Values
MH  - Risk Factors
MH  - Senegal
MH  - Valine
EDAT- 1995/05/01 00:00
MHDA- 1995/05/01 00:01
CRDT- 1995/05/01 00:00
PHST- 1995/05/01 00:00 [pubmed]
PHST- 1995/05/01 00:01 [medline]
PHST- 1995/05/01 00:00 [entrez]
AID - 10.2337/diacare.18.5.677 [doi]
PST - ppublish
SO  - Diabetes Care. 1995 May;18(5):677-80. doi: 10.2337/diacare.18.5.677.