PMID- 8586444 OWN - NLM STAT- MEDLINE DCOM- 19960325 LR - 20071114 IS - 0888-7543 (Print) IS - 0888-7543 (Linking) VI - 30 IP - 2 DP - 1995 Nov 20 TI - The interferon-inducible, double-stranded RNA-specific adenosine deaminase gene (DSRAD) maps to human chromosome 1q21.1-21.2. PG - 372-5 AB - The interferon-inducible double-stranded RNA-specific adenosine deaminase is an RNA-modifying enzyme implicated in the generation of biased hypermutations viral RNAs and the site-selective editing of mammalian mRNAs of neural origin. The gene for the dsRNA-specific adenosine deaminase has been mapped by fluorescence in situ hybridization (FISH) of genomic clones to a single locus on human chromosome 1 bands q21.1-21.2. Simultaneous multicolor FISH including lambda clones and yeast artificial chromosomes showed a localization of the gene in band 1q21 centromeric of D1S1705. FAU - Weier, H U AU - Weier HU AD - Center for Molecular Cytogenetics, University of California, Lawrence Berkeley National Laboratory 94720, USA. FAU - George, C X AU - George CX FAU - Greulich, K M AU - Greulich KM FAU - Samuel, C E AU - Samuel CE LA - eng GR - AI-12520/AI/NIAID NIH HHS/United States PT - Journal Article PT - Research Support, U.S. Gov't, Non-P.H.S. PT - Research Support, U.S. Gov't, P.H.S. PL - United States TA - Genomics JT - Genomics JID - 8800135 RN - 0 (RNA, Double-Stranded) RN - 9008-11-1 (Interferons) RN - EC 3.5.4.4 (Adenosine Deaminase) SB - IM MH - Adenosine Deaminase/*genetics/metabolism MH - Chromosome Mapping MH - Chromosomes, Artificial, Yeast MH - *Chromosomes, Human, Pair 1 MH - *Gene Expression Regulation, Enzymologic MH - Humans MH - In Situ Hybridization, Fluorescence MH - Interferons/*pharmacology MH - RNA, Double-Stranded/*metabolism EDAT- 1995/11/20 00:00 MHDA- 1995/11/20 00:01 CRDT- 1995/11/20 00:00 PHST- 1995/11/20 00:00 [pubmed] PHST- 1995/11/20 00:01 [medline] PHST- 1995/11/20 00:00 [entrez] AID - S0888-7543(85)70034-1 [pii] AID - 10.1006/geno.1995.0034 [doi] PST - ppublish SO - Genomics. 1995 Nov 20;30(2):372-5. doi: 10.1006/geno.1995.0034.