PMID- 8587148
OWN - NLM
STAT- MEDLINE
DCOM- 19960325
LR  - 20190920
IS  - 0140-7783 (Print)
IS  - 0140-7783 (Linking)
VI  - 18
IP  - 5
DP  - 1995 Oct
TI  - Dietary intake estimates as a means to the harmonization of maximum residue 
      levels for veterinary drugs. I. Concept.
PG  - 325-7
AB  - The harmonization of standards and procedures for establishing tolerances or 
      maximum residue levels (MRLs) for veterinary drug residues in edible animal 
      products is a major goal of the international veterinary drug community. Such 
      harmonization would contribute to easing trade barriers. This paper proposes use 
      of the toxicologically determined acceptable daily intake (ADI) for the drug as 
      the safety standard for reaching conclusions on the acceptability of residues in 
      meat for human consumption. Specifically, the 'equivalence' of different MRLs for 
      the same veterinary drug would be determined by considering whether they are 
      likely to result in dietary residues that exceed another country's ADI for the 
      drug. Two methods of estimating dietary intake are described, and estimates are 
      made for the veterinary drugs albendazole and ivermectin. Based on these 
      estimates, the US and JECFA MRLs for each drug would be considered 'equivalent' 
      for trade purposes.
FAU - Fitzpatrick, S C
AU  - Fitzpatrick SC
AD  - Centre for Veterinary Medicine, U.S. Food and Drug Administration, Rockville, 
      Maryland 20855, USA.
FAU - Brynes, S D
AU  - Brynes SD
FAU - Guest, G B
AU  - Guest GB
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Vet Pharmacol Ther
JT  - Journal of veterinary pharmacology and therapeutics
JID - 7910920
RN  - 0 (Anthelmintics)
RN  - 70288-86-7 (Ivermectin)
RN  - F4216019LN (Albendazole)
SB  - IM
MH  - Albendazole/administration & dosage/*analysis
MH  - Animals
MH  - Anthelmintics/administration & dosage/*analysis
MH  - Diet
MH  - Drug Residues/analysis/*standards
MH  - Eating
MH  - Food-Drug Interactions
MH  - Guidelines as Topic
MH  - Humans
MH  - International Cooperation
MH  - Ivermectin/administration & dosage/*analysis
MH  - Meat Products/analysis/*standards
MH  - Therapeutic Equivalency
MH  - World Health Organization
EDAT- 1995/10/01 00:00
MHDA- 1995/10/01 00:01
CRDT- 1995/10/01 00:00
PHST- 1995/10/01 00:00 [pubmed]
PHST- 1995/10/01 00:01 [medline]
PHST- 1995/10/01 00:00 [entrez]
AID - 10.1111/j.1365-2885.1995.tb00598.x [doi]
PST - ppublish
SO  - J Vet Pharmacol Ther. 1995 Oct;18(5):325-7. doi: 
      10.1111/j.1365-2885.1995.tb00598.x.