PMID- 8588307 OWN - NLM STAT- MEDLINE DCOM- 19960325 LR - 20190830 IS - 0378-1135 (Print) IS - 0378-1135 (Linking) VI - 44 IP - 2-4 DP - 1995 May TI - Measles virus infection of cerebral endothelial cells and effect on their adhesive properties. PG - 135-9 AB - Measles virus (MV) RNA is present in endothelial cells (Ec) in brain tissue from cases of subacute sclerosing panencephalitis (SSPE) and relatively high titres of infectious virus are produced in human cerebral Ec in vitro. Infection of Ec at the blood-brain barrier could therefore provide the opportunity for entry of virus to the CNS. Adhesion of syngeneic splenocytes to MV infected murine (Balb/c) cerebral Ec is found to be upregulated. Increased expression of endothelial adhesion molecules, following virus infection at the blood-brain-barrier, may be an important mechanism in inducing inflammatory infiltration of the CNS in SSPE. FAU - Cosby, S L AU - Cosby SL AD - Division of Molecular Biology, School of Biology and Biochemistry, Queen's University of Belfast, UK. FAU - Brankin, B AU - Brankin B LA - eng PT - Journal Article PT - Review PL - Netherlands TA - Vet Microbiol JT - Veterinary microbiology JID - 7705469 SB - IM MH - Animals MH - Brain/cytology/*virology MH - Cell Adhesion/physiology MH - Endothelium/cytology/virology MH - Humans MH - Leukocytes/*physiology MH - Measles virus/*pathogenicity MH - Mice MH - Mice, Inbred BALB C MH - Subacute Sclerosing Panencephalitis/*virology RF - 21 EDAT- 1995/05/01 00:00 MHDA- 1995/05/01 00:01 CRDT- 1995/05/01 00:00 PHST- 1995/05/01 00:00 [pubmed] PHST- 1995/05/01 00:01 [medline] PHST- 1995/05/01 00:00 [entrez] AID - 0378-1135(95)00006-V [pii] AID - 10.1016/0378-1135(95)00006-v [doi] PST - ppublish SO - Vet Microbiol. 1995 May;44(2-4):135-9. doi: 10.1016/0378-1135(95)00006-v.