PMID- 8593266 OWN - NLM STAT- MEDLINE DCOM- 19960409 LR - 20191024 IS - 0923-1811 (Print) IS - 0923-1811 (Linking) VI - 10 IP - 3 DP - 1995 Nov TI - The effect of hepatocyte growth factor/scatter factor on human hair follicle growth. PG - 229-32 AB - The effect of hepatocyte growth factor/scatter factor (HGF/SF) on human hair follicle growth was examined using a serum-free organ culture system. The DNA synthesis in human hair follicles and elongation of the hair shaft were measured subsequent to the follicle isolation and culture at 31 degrees C in 95% O2-5% CO2 for 72 h. Results showed that HGF/SF significantly increased 3H-thymidine (P < 0.001) incorporation and hair follicle length (P < 0.05). The effect of HGF/SF was dose-dependent with a maximal stimulation at 10 ng/ml. FAU - Jindo, T AU - Jindo T AD - Department of Dermatology, Juntendo University School of Medicine, Tokyo, Japan. FAU - Tsuboi, R AU - Tsuboi R FAU - Imai, R AU - Imai R FAU - Takamori, K AU - Takamori K FAU - Rubin, J S AU - Rubin JS FAU - Ogawa, H AU - Ogawa H LA - eng PT - Journal Article PL - Netherlands TA - J Dermatol Sci JT - Journal of dermatological science JID - 9011485 RN - 67256-21-7 (Hepatocyte Growth Factor) RN - 9007-49-2 (DNA) SB - IM MH - Adolescent MH - DNA/biosynthesis MH - Hair Follicle/*drug effects/*growth & development/metabolism MH - Hepatocyte Growth Factor/*pharmacology MH - Humans MH - Organ Culture Techniques EDAT- 1995/11/01 00:00 MHDA- 1995/11/01 00:01 CRDT- 1995/11/01 00:00 PHST- 1995/11/01 00:00 [pubmed] PHST- 1995/11/01 00:01 [medline] PHST- 1995/11/01 00:00 [entrez] AID - 092318119500429V [pii] AID - 10.1016/0923-1811(95)00429-v [doi] PST - ppublish SO - J Dermatol Sci. 1995 Nov;10(3):229-32. doi: 10.1016/0923-1811(95)00429-v.