PMID- 8594309
OWN - NLM
STAT- MEDLINE
DCOM- 19960408
LR  - 20190701
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 58
IP  - 5
DP  - 1996
TI  - Cardiovascular effects of centrally administered endothelin-1 and its 
      relationship to changes in cerebral blood flow.
PG  - 437-45
AB  - Intracerebroventricular (i.c.v.) injection of endothelin-1 (ET-1; 100 ng. i.c.v.) 
      produced an initial pressor (24%) (peak at 3 min following ET-1 administration) 
      and a delayed depressor (-40%) (30 and 60 min following ET-1 administration) 
      effects in urethane anesthetized rats. The pressor effect of ET-1 was due to an 
      increase (21%) in cardiac output, while the depressor effect of ET-1 was 
      associated with a marked decrease (-46%) in cardiac output. Stroke volume 
      significantly decreased at 30 and 60 min after the administration of ET-1. No 
      change in total peripheral vascular resistance and heart rate was observed 
      following central administration of ET-1. The effects of ET-1 on Blood pressure, 
      cardiac output and stroke volume were not observed in BQ123 (10 micrograms, 
      i.c.v.) treated rats. Blood flow to the cerebral hemispheres, cerebellum, 
      midbrain and brain stem was not affected at 3 min, but a significant decrease in 
      blood flow to all the regions of the brain was observed at 30 and 60 min 
      following central administration of ET-1. BQ123 pretreatment completely blocked 
      the central ET-1 induced decrease in blood flow to the brain regions. It is 
      concluded that the pressor effect of centrally administered ET-1 is not 
      accompanied by a severe decrease in brain blood flow, however, a subsequent 
      decrease in blood pressure is associated with a decrease in blood flow to the 
      brain. The cardiovascular effects of ET-1 including decrease in brain blood flow 
      are mediated through central ET receptors.
FAU - Gulati, A
AU  - Gulati A
AD  - Department of Pharmaceutics & Pharmacodynamics, The University of Illinois at 
      Chicago, Chicago IL 60612, USA.
FAU - Kumar, A
AU  - Kumar A
FAU - Shahani, B T
AU  - Shahani BT
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Endothelins)
SB  - IM
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Brain/*blood supply
MH  - Cardiac Output/drug effects
MH  - Cerebral Ventricles/drug effects/*physiology
MH  - Cerebrovascular Circulation/drug effects/*physiology
MH  - Endothelins/administration & dosage/*pharmacology
MH  - Heart Rate/drug effects
MH  - Hemodynamics/*drug effects
MH  - Injections, Intraventricular
MH  - Male
MH  - Organ Specificity
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Regional Blood Flow/drug effects
MH  - Stroke Volume/drug effects
MH  - Time Factors
MH  - Vascular Resistance/drug effects
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 0024320595023097 [pii]
AID - 10.1016/0024-3205(95)02309-7 [doi]
PST - ppublish
SO  - Life Sci. 1996;58(5):437-45. doi: 10.1016/0024-3205(95)02309-7.