PMID- 8596038
OWN - NLM
STAT- MEDLINE
DCOM- 19960415
LR  - 20071114
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 156
IP  - 5
DP  - 1996 Mar 1
TI  - Receptors on T cells escaping superantigen-mediated deletion lack special 
      beta-chain junctional region structural characteristics.
PG  - 1865-72
AB  - The TCR V beta element is pivotal for superantigen recognition; however, not all 
      T cells bearing a particular V beta element respond to an individual 
      superantigen. Recent evidence has indicated that the TCR V alpha element also 
      contributes to recognition of superantigen/MHC class II complexes. To determine 
      whether the TCR beta-chain junctional regions influence recognition of a 
      superantigen encoded by mouse mammary tumor virus (MMTV) proviral integrant 
      Mtv-1, we have analyzed these regions in T cells that have survived 
      superantigen-mediated negative selection in B10.BR-Mtv-1 mice. Our data indicate: 
      1) no TCR J beta skewing, 2) no difference in the length of the third 
      complementarity-determining region (CDR3), and 3) no outstanding structural 
      features that are shared among the junctional regions of the V beta 3+ T cells 
      that escape thymic clonal elimination in superantigen-expressing mice. Several 
      possible models for TCR engagement of viral superantigen/MHC class II complexes 
      are discussed.
FAU - Pullen, A M
AU  - Pullen AM
AD  - Department of Immunology, University of Washington, Seattle, WA 98195, USA.
FAU - Bogatzki, L Y
AU  - Bogatzki LY
LA  - eng
SI  - GENBANK/X94822
SI  - GENBANK/X94823
SI  - GENBANK/X94824
SI  - GENBANK/X94825
SI  - GENBANK/X94826
SI  - GENBANK/X94827
SI  - GENBANK/X94828
SI  - GENBANK/X94829
SI  - GENBANK/X94830
SI  - GENBANK/X94831
SI  - GENBANK/X94832
SI  - GENBANK/X94833
SI  - GENBANK/X94834
SI  - GENBANK/X94835
SI  - GENBANK/X94836
SI  - GENBANK/X94837
SI  - GENBANK/X94838
SI  - GENBANK/X94839
SI  - GENBANK/X94840
SI  - GENBANK/X94841
SI  - GENBANK/X94842
SI  - GENBANK/X94843
SI  - GENBANK/X94844
SI  - GENBANK/X94845
SI  - GENBANK/X94846
SI  - GENBANK/X94847
SI  - GENBANK/X94848
SI  - GENBANK/X94849
SI  - GENBANK/X94850
SI  - GENBANK/X94851
GR  - AI-33528/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Receptors, Antigen, T-Cell, alpha-beta)
RN  - 0 (Superantigens)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Antigen Presentation/genetics
MH  - Base Composition
MH  - Base Sequence
MH  - Clonal Deletion/*genetics/immunology
MH  - Hybridomas
MH  - Mammary Tumor Virus, Mouse/immunology
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Mice, Inbred C57BL
MH  - Molecular Sequence Data
MH  - Multigene Family/immunology
MH  - Proviruses/immunology
MH  - Receptors, Antigen, T-Cell, alpha-beta/*chemistry/genetics
MH  - Structure-Activity Relationship
MH  - Superantigens/*immunology
MH  - T-Lymphocytes/*immunology
EDAT- 1996/03/01 00:00
MHDA- 1996/03/01 00:01
CRDT- 1996/03/01 00:00
PHST- 1996/03/01 00:00 [pubmed]
PHST- 1996/03/01 00:01 [medline]
PHST- 1996/03/01 00:00 [entrez]
PST - ppublish
SO  - J Immunol. 1996 Mar 1;156(5):1865-72.