PMID- 8597162
OWN - NLM
STAT- MEDLINE
DCOM- 19960415
LR  - 20190819
IS  - 0378-4274 (Print)
IS  - 0378-4274 (Linking)
VI  - 82-83
DP  - 1995 Dec
TI  - Receptors as tools for understanding the toxicity of retinoids.
PG  - 91-7
AB  - Retinoids are derivatives of vitamin A that have numerous biologic activities 
      including induction of epithelial differentiation, pattern formation in embryos, 
      and maintenance of spermatogenesis. Retinoids are used to treat various 
      dermatologic maladies and specific forms of cancer but their use is limited by 
      toxic liabilities: most notably teratogenesis. Retinoids interact with 2 families 
      of receptors, the retinoic acid receptors (RARs) and retinoid X receptors (RXRs). 
      The RARs and RXRs bind and transactivate distinct response elements of numerous 
      genes. This multiplicity of receptors and gene products provides us with multiple 
      targets for developing novel receptor-selective agonists. We are exploiting our 
      knowledge of ligand receptor interactions to design better, more selective drugs 
      and to understand the toxicity of retinoids and their metabolic products.
FAU - Levin, A A
AU  - Levin AA
AD  - Department of Toxicology and Pathology, Hoffmann-La Roche, Nutley, NJ, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Toxicol Lett
JT  - Toxicology letters
JID - 7709027
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Retinoids)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Receptors, Retinoic Acid/*physiology
MH  - Retinoid X Receptors
MH  - Retinoids/*toxicity
MH  - Transcription Factors/*physiology
RF  - 57
EDAT- 1995/12/01 00:00
MHDA- 1995/12/01 00:01
CRDT- 1995/12/01 00:00
PHST- 1995/12/01 00:00 [pubmed]
PHST- 1995/12/01 00:01 [medline]
PHST- 1995/12/01 00:00 [entrez]
AID - 0378-4274(95)03546-X [pii]
AID - 10.1016/0378-4274(95)03546-x [doi]
PST - ppublish
SO  - Toxicol Lett. 1995 Dec;82-83:91-7. doi: 10.1016/0378-4274(95)03546-x.