PMID- 8597637
OWN - NLM
STAT- MEDLINE
DCOM- 19960423
LR  - 20200304
IS  - 0938-8990 (Print)
IS  - 0938-8990 (Linking)
VI  - 6
IP  - 11
DP  - 1995 Nov
TI  - Mapping of the calcium-sensing receptor gene (CASR) to human chromosome 3q13.3-21 
      by fluorescence in situ hybridization, and localization to rat chromosome 11 and 
      mouse chromosome 16.
PG  - 798-801
AB  - The calcium-sensing receptor (CASR), a member of the G-protein coupled receptor 
      family, is expressed in both parathyroid and kidney, and aids these organs in 
      sensing extracellular calcium levels. Inactivating mutations in the CASR gene 
      have been described in familial hypocalciuric hypercalcemia (FHH) and neonatal 
      severe hyperparathyroidism (NSHPT). Activating mutations in the CASR gene have 
      been described in autosomal dominant hypoparathyroidism and familial 
      hypocalcemia. The human CASR gene was mapped to Chromosome (Chr) 3q13.3-21 by 
      fluorescence in situ hybridization (FISH). By somatic cell hybrid analysis, the 
      gene was localized to human Chr 3 (hybridization to other chromosomes was not 
      observed) and rat Chr 11. By interspecific backcross analysis, the Casr gene 
      segregated with D16Mit4 on mouse Chr 16. These findings extend our knowledge of 
      the synteny conservation of human Chr 3, rat Chr 11, and mouse Chr 16.
FAU - Janicic, N
AU  - Janicic N
AD  - Calcium Research Laboratory, McGill University, Montreal, Quebec, Canada.
FAU - Soliman, E
AU  - Soliman E
FAU - Pausova, Z
AU  - Pausova Z
FAU - Seldin, M F
AU  - Seldin MF
FAU - Riviere, M
AU  - Riviere M
FAU - Szpirer, J
AU  - Szpirer J
FAU - Szpirer, C
AU  - Szpirer C
FAU - Hendy, G N
AU  - Hendy GN
LA  - eng
GR  - HG00734/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Mamm Genome
JT  - Mammalian genome : official journal of the International Mammalian Genome Society
JID - 9100916
RN  - 0 (DNA, Complementary)
RN  - 0 (Receptors, Calcium-Sensing)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (extracellular calcium cation-sensing receptor, rat)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - *Chromosome Mapping
MH  - *Chromosomes, Human, Pair 3
MH  - DNA, Complementary
MH  - Female
MH  - Humans
MH  - Hybrid Cells
MH  - Hypercalcemia/genetics
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Mice
MH  - Molecular Sequence Data
MH  - Polymerase Chain Reaction
MH  - Rats
MH  - Receptors, Calcium-Sensing
MH  - Receptors, Cell Surface/*genetics
EDAT- 1995/11/01 00:00
MHDA- 1995/11/01 00:01
CRDT- 1995/11/01 00:00
PHST- 1995/11/01 00:00 [pubmed]
PHST- 1995/11/01 00:01 [medline]
PHST- 1995/11/01 00:00 [entrez]
AID - 10.1007/BF00539007 [doi]
PST - ppublish
SO  - Mamm Genome. 1995 Nov;6(11):798-801. doi: 10.1007/BF00539007.