PMID- 8597959
OWN - NLM
STAT- MEDLINE
DCOM- 19960422
LR  - 20190914
IS  - 1078-8956 (Print)
IS  - 1078-8956 (Linking)
VI  - 2
IP  - 4
DP  - 1996 Apr
TI  - Protection of auditory neurons from aminoglycoside toxicity by neurotrophin-3.
PG  - 463-7
AB  - Hearing is conveyed from the auditory receptors, the hair cells in the organ of 
      Corti, to the brain via the spiral ganglion neurons. Damage or loss of either 
      spiral ganglion neurons or hair cells causes hearing impairment. Such hearing 
      disorders are often permanent and can be caused by therapeutic agents, such as 
      aminoglycoside antibiotics and cisplatin, or by aging, loud sounds, infections 
      and mechanical injury (1). Brain-derived neurotrophic factor (BDNF) and 
      neurotrophin-3 (NT-3), members of the neurotrohin family of neurotrophic factors 
      that also include nerve growth factor (NGF) and neurotrophin-4/5 (NT-4), are 
      important in development of the neuronal components of the inner ear. We report 
      here that the loss of target innervation and the degeneration of approximately 
      90% of the adult spiral ganglion neurons caused by aminoglycoside toxicity can be 
      prevented by infusion of the neurotrophic factor, neurotrophin-3 (NT-3) in the 
      membranous labyrinth in guinea pigs. The potency of NT-3 in protecting spiral 
      ganglion neurons from degenerating suggests that neurotrophins may be useful for 
      the treatment of hearing disorders.
FAU - Ernfors, P
AU  - Ernfors P
AD  - Department of Medical Biochemistry and Biophysics, Laboratory of Molecular 
      Neurobiology, Karolinska Institute, Stockholm, Sweden.
FAU - Duan, M L
AU  - Duan ML
FAU - ElShamy, W M
AU  - ElShamy WM
FAU - Canlon, B
AU  - Canlon B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Nat Med
JT  - Nature medicine
JID - 9502015
RN  - 0 (Aminoglycosides)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neurotrophin 3)
SB  - IM
MH  - Aminoglycosides/*toxicity
MH  - Animals
MH  - Cell Count
MH  - Cell Death/drug effects
MH  - Guinea Pigs
MH  - Hearing Disorders/chemically induced/*prevention & control
MH  - Nerve Growth Factors/*therapeutic use
MH  - Neurons/drug effects/pathology
MH  - Neurotrophin 3
MH  - Spiral Ganglion/*drug effects/pathology
EDAT- 1996/04/01 00:00
MHDA- 1996/04/01 00:01
CRDT- 1996/04/01 00:00
PHST- 1996/04/01 00:00 [pubmed]
PHST- 1996/04/01 00:01 [medline]
PHST- 1996/04/01 00:00 [entrez]
AID - 10.1038/nm0496-463 [doi]
PST - ppublish
SO  - Nat Med. 1996 Apr;2(4):463-7. doi: 10.1038/nm0496-463.