PMID- 8598110
OWN - NLM
STAT- MEDLINE
DCOM- 19960419
LR  - 20190722
IS  - 0009-9147 (Print)
IS  - 0009-9147 (Linking)
VI  - 42
IP  - 3
DP  - 1996 Mar
TI  - Effect of renal function on serum nitrogen oxide concentrations.
PG  - 440-4
AB  - Nitric oxide is too short-lived to measure in vivo, but its production can be 
      estimated by measuring its stable oxidation products, nitrites and nitrates, in 
      serum. Renal elimination of these ions has been demonstrated, but the effect of 
      renal function on their concentrations in serum is currently unknown. We 
      evaluated serum and urine nitrates + nitrites as serum nitrogen oxides (sNOx), 
      nitrogen oxide (NOx) clearance, and creatinine clearance in 71 patients on the 
      Intensive Therapy Unit. The correlation between sNOx and plasma creatinine was 
      strong and highly significant (P <0.001). These results suggest that renal 
      function has a significant effect on sNOx concentrations. Studies in which the 
      sNOx concentration is used as an index of nitric oxide production can therefore 
      be interpreted only if renal function has been taken into account.
FAU - Mackenzie, I M
AU  - Mackenzie IM
AD  - Department of Intensive Care, Royal North Shore Hospital, Sydney, Australia.
FAU - Ekangaki, A
AU  - Ekangaki A
FAU - Young, J D
AU  - Young JD
FAU - Garrard, C S
AU  - Garrard CS
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Chem
JT  - Clinical chemistry
JID - 9421549
RN  - 0 (Nitrates)
RN  - 0 (Nitrites)
RN  - 0 (Nitrogen Oxides)
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - Kidney/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Nitrates/blood/urine
MH  - Nitric Oxide/metabolism
MH  - Nitrites/blood/urine
MH  - Nitrogen Oxides/*blood/urine
MH  - Renal Insufficiency/*blood/physiopathology/urine
EDAT- 1996/03/01 00:00
MHDA- 1996/03/01 00:01
CRDT- 1996/03/01 00:00
PHST- 1996/03/01 00:00 [pubmed]
PHST- 1996/03/01 00:01 [medline]
PHST- 1996/03/01 00:00 [entrez]
PST - ppublish
SO  - Clin Chem. 1996 Mar;42(3):440-4.