PMID- 8598307
OWN - NLM
STAT- MEDLINE
DCOM- 19960423
LR  - 20160303
IS  - 0020-7136 (Print)
IS  - 0020-7136 (Linking)
VI  - 65
IP  - 5
DP  - 1996 Mar 1
TI  - Sero-epidemiological analysis of the risk of virus infections for childhood 
      leukaemia.
PG  - 584-90
AB  - Virus infections have been thought to be involved in the development of childhood 
      leukaemia. In order to address this issue we determined, in a case-control study, 
      the prevalence of antibodies to viruses infecting blood or bone-marrow cells 
      [Epstein-Barr virsus (EBV), human herpes virus type 6 (HHV-6), parvovirus B19] as 
      well as to the human virus known for its tumour-suppressive properties, the 
      adeno-associated virus type 2 (AAV-2), in the sera of 121 children with leukaemia 
      in Germany, and in 197 control individuals, hospitalized for other reasons, and 
      matched for age and gender to the cases. In addition, we developed a 
      questionnaire to be answered by the children's parents, in order to gain 
      information on previous infections of the children as well as to calculate for 
      factors which may influence serological findings. Comparative determination of 
      the prevalence of antibodies against AAV-2, B-19 or HHV-6 revealed no significant 
      differences in cases and controls. However, antibodies to EBV were more 
      frequently found in children with leukaemia younger than 6 years of age (age at 
      the time of diagnosis of leukaemia) than in controls. Apparently, infection with 
      AAV-2 has no protective effect in childhood leukaemia, in contrast to results 
      observed for other malignancies. Similarly, and in accordance with results on 
      leukaemia in adults, we found no indication of a protective effect of infection 
      with the parvovirus B-19. The data suggest that EBV, which is known to be 
      involved in various lymphomas, may play a role in the development of childhood 
      leukaemia in young children.
FAU - Schlehofer, B
AU  - Schlehofer B
AD  - Division of Epidemiology, German Cancer Research Centre, Heidelberg, Germany.
FAU - Blettner, M
AU  - Blettner M
FAU - Geletneky, K
AU  - Geletneky K
FAU - Haaf, H G
AU  - Haaf HG
FAU - Kaatsch, P
AU  - Kaatsch P
FAU - Michaelis, J
AU  - Michaelis J
FAU - Mueller-Lantzsch, N
AU  - Mueller-Lantzsch N
FAU - Niehoff, D
AU  - Niehoff D
FAU - Winkelspecht, B
AU  - Winkelspecht B
FAU - Wahrendorf, J
AU  - Wahrendorf J
FAU - Schlehofer, J R
AU  - Schlehofer JR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - 0 (Antibodies, Viral)
SB  - IM
MH  - Adolescent
MH  - Antibodies, Viral/analysis
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Dependovirus
MH  - Female
MH  - Germany
MH  - Herpesviridae Infections/*complications
MH  - Herpesvirus 4, Human
MH  - Herpesvirus 6, Human
MH  - Humans
MH  - Immunophenotyping
MH  - Infant
MH  - Leukemia/*microbiology
MH  - Male
MH  - Maternal Age
MH  - Parvoviridae Infections/*complications
MH  - Parvovirus B19, Human
MH  - Paternal Age
MH  - Risk
MH  - Virus Diseases/complications
EDAT- 1996/03/01 00:00
MHDA- 2000/06/20 09:00
CRDT- 1996/03/01 00:00
PHST- 1996/03/01 00:00 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1996/03/01 00:00 [entrez]
AID - 10.1002/(SICI)1097-0215(19960301)65:5<584::AID-IJC5>3.0.CO;2-Z [pii]
AID - 10.1002/(SICI)1097-0215(19960301)65:5<584::AID-IJC5>3.0.CO;2-Z [doi]
PST - ppublish
SO  - Int J Cancer. 1996 Mar 1;65(5):584-90. doi: 
      10.1002/(SICI)1097-0215(19960301)65:5<584::AID-IJC5>3.0.CO;2-Z.