PMID- 8600614
OWN - NLM
STAT- MEDLINE
DCOM- 19960502
LR  - 20190819
IS  - 0378-4274 (Print)
IS  - 0378-4274 (Linking)
VI  - 84
IP  - 3
DP  - 1996 Mar
TI  - Effect of hyperthyroidism on the biliary release of thiobarbituric acid reactants 
      in the rat.
PG  - 149-53
AB  - The influence of daily doses of 0.1 mg 3,3',5-triiodothyronine (T3)/kg for three 
      consecutive days on hepatic lipid peroxidation was assessed by the biliary 
      release of thiobarbituric acid reactants (TBARS) in anesthetized rats. T3 
      treatment elicited a significant 80% increase in the biliary efflux of TBARS 
      compared to control values, an effect determined by increments in both the TBARS 
      concentration in bile (44%) and in the bile flow (25%). It is concluded that 
      hyperthyroidism-induced oxidative stress stimulates hepatic lipid peroxidation 
      measured in an in situ liver preparation, which significantly correlates with the 
      enhancement in the rate of TBARS production assessed in liver homogenates.
FAU - Fernandez, V
AU  - Fernandez V
AD  - Departamento de Bioquimica, Facultad de Medicina, Universidad de Chile, Santiago, 
      Chile.
FAU - Videla, L A
AU  - Videla LA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Toxicol Lett
JT  - Toxicology letters
JID - 7709027
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 06LU7C9H1V (Triiodothyronine)
SB  - IM
MH  - Animals
MH  - Bile/*metabolism
MH  - Body Weight/drug effects
MH  - Female
MH  - Hyperthyroidism/*metabolism
MH  - Injections, Intraperitoneal
MH  - Lipid Peroxidation/*drug effects
MH  - Liver/drug effects/*metabolism
MH  - Organ Size/drug effects
MH  - Oxidative Stress
MH  - Oxygen Consumption/drug effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Thiobarbituric Acid Reactive Substances/*metabolism
MH  - Triiodothyronine/administration & dosage/blood/*pharmacology
EDAT- 1996/03/01 00:00
MHDA- 1996/03/01 00:01
CRDT- 1996/03/01 00:00
PHST- 1996/03/01 00:00 [pubmed]
PHST- 1996/03/01 00:01 [medline]
PHST- 1996/03/01 00:00 [entrez]
AID - 0378427495036172 [pii]
AID - 10.1016/0378-4274(95)03617-2 [doi]
PST - ppublish
SO  - Toxicol Lett. 1996 Mar;84(3):149-53. doi: 10.1016/0378-4274(95)03617-2.