PMID- 8601742
OWN - NLM
STAT- MEDLINE
DCOM- 19960503
LR  - 20221207
IS  - 0022-202X (Print)
IS  - 0022-202X (Linking)
VI  - 106
IP  - 2
DP  - 1996 Feb
TI  - HLA-DR4 may determine expression of actinic prurigo in British patients.
PG  - 362-7
AB  - Human leukocyte antigen (HLA) associations have been reported in Amerindian 
      patients with actinic prurigo. To determine if similar associations are present 
      in the British Caucasoid population with actinic prurigo, 26 patients underwent 
      serological typing for HLC Class I and II antigens. DNA analysis by both 
      sequence-specific priming and group-specific amplification with single-stranded 
      oligonucleotide probe hybridization was used to confirm the DR and DQ typing and 
      to perform DR4 subtyping. All patients were DR4 positive, and 25 of 26 patients 
      were DQ7 positive. DR4 subtyping revealed 12 of 20 patients tested to be 
      DRB1*0407. A nonsignificant association was also found with HLA B55 that is in 
      linkage disequilibrium with DRB1*0407. No HLA associations were found in 25 
      British Caucasoid patients with polymorphic light eruption. DRB1*0407 is rare in 
      European Caucasoids without actinic prurigo, and HLA-DR4 may have an important 
      role in determining expression of this disease.
FAU - Menage H duP
AU  - Menage H duP
AD  - Photobiology Department, St. John's Institute of Dermatology, London, U.K.
FAU - Vaughan, R W
AU  - Vaughan RW
FAU - Baker, C S
AU  - Baker CS
FAU - Page, G
AU  - Page G
FAU - Proby, C M
AU  - Proby CM
FAU - Breathnach, S M
AU  - Breathnach SM
FAU - Hawk, J L
AU  - Hawk JL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Invest Dermatol
JT  - The Journal of investigative dermatology
JID - 0426720
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-DR4 Antigen)
SB  - IM
CIN - J Invest Dermatol. 1997 Feb;108(2):233-4. PMID: 9008241
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Female
MH  - HLA-A Antigens/analysis/blood
MH  - HLA-B Antigens/blood
MH  - HLA-C Antigens/blood
MH  - HLA-DR4 Antigen/*analysis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Photosensitivity Disorders/epidemiology/ethnology/*immunology
MH  - Prurigo/epidemiology/ethnology/*immunology
MH  - United Kingdom/epidemiology
MH  - White People
EDAT- 1996/02/01 00:00
MHDA- 1996/02/01 00:01
CRDT- 1996/02/01 00:00
PHST- 1996/02/01 00:00 [pubmed]
PHST- 1996/02/01 00:01 [medline]
PHST- 1996/02/01 00:00 [entrez]
AID - S0022-202X(15)42454-6 [pii]
AID - 10.1111/1523-1747.ep12343141 [doi]
PST - ppublish
SO  - J Invest Dermatol. 1996 Feb;106(2):362-7. doi: 10.1111/1523-1747.ep12343141.