PMID- 8601789
OWN - NLM
STAT- MEDLINE
DCOM- 19960503
LR  - 20061115
IS  - 0022-1317 (Print)
IS  - 0022-1317 (Linking)
VI  - 77 ( Pt 3)
DP  - 1996 Mar
TI  - Identification of an 85 kDa phosphoprotein as an immunodominant protein specific 
      for human herpesvirus 7-infected cells.
PG  - 511-8
AB  - The reactivity of human cord blood sera was directed most frequently in Western 
      blot assays to a protein with an apparent molecular mass of 85 kDa that belongs 
      to the p85 complex, a family of antigenically related proteins identified 
      previously in our laboratory with the aid of two MAbs. We show that the 85 kDa 
      protein is phosphorylated. As antibodies present in the human sera were directed 
      in part to proteins carrying cross-reactive epitopes between human herpesvirus 6 
      (HHV-6) and 7 (HHV-7), it is remarkable that reactivity to the 85 kDa 
      phosphoprotein was maintained after preabsorption of the sera with HHV-6 antigen, 
      but abolished after preabsorption with HHV-7 antigen. Therefore, the 85 kDa 
      phosphoprotein may be considered a major determinant of the human immune response 
      to HHV-7, discriminating HHV-6 from HHV-7 infection.
FAU - Foa-Tomasi, L
AU  - Foa-Tomasi L
AD  - Department of Experimental Pathology, Section of Microbiology and Virology, 
      University of Bologna, Italy.
FAU - Fiorilli, M P
AU  - Fiorilli MP
FAU - Avitabile, E
AU  - Avitabile E
FAU - Campadelli-Fiume, G
AU  - Campadelli-Fiume G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Gen Virol
JT  - The Journal of general virology
JID - 0077340
RN  - 0 (Immunodominant Epitopes)
RN  - 0 (Phosphoproteins)
RN  - 0 (Viral Proteins)
SB  - IM
MH  - Cross Reactions
MH  - Fetal Blood
MH  - Herpesvirus 6, Human/immunology
MH  - Herpesvirus 7, Human/*immunology
MH  - Humans
MH  - Immunodominant Epitopes/*immunology
MH  - Phosphoproteins/*immunology
MH  - Viral Proteins/*immunology
EDAT- 1996/03/01 00:00
MHDA- 1996/03/01 00:01
CRDT- 1996/03/01 00:00
PHST- 1996/03/01 00:00 [pubmed]
PHST- 1996/03/01 00:01 [medline]
PHST- 1996/03/01 00:00 [entrez]
AID - 10.1099/0022-1317-77-3-511 [doi]
PST - ppublish
SO  - J Gen Virol. 1996 Mar;77 ( Pt 3):511-8. doi: 10.1099/0022-1317-77-3-511.