PMID- 8601816
OWN - NLM
STAT- MEDLINE
DCOM- 19960509
LR  - 20220321
IS  - 0270-6474 (Print)
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Linking)
VI  - 16
IP  - 7
DP  - 1996 Apr 1
TI  - Chronic antidepressant administration increases the expression of cAMP response 
      element binding protein (CREB) in rat hippocampus.
PG  - 2365-72
AB  - The present study demonstrates that chronic, but not acute, adminstration of 
      several different classes of antidepressants, including serotonin- and 
      norepinephrine-selective reuptake inhibitors, increases the expression of cAMP 
      response element binding protein (CREB) mRNA in rat hippocampus. In contrast, 
      chronic administration of several nonantidepressant psychotropic drugs did not 
      influence expression of CREB mRNA, demonstrating the pharmacological specificity 
      of this effect. In situ hybridization analysis demonstrates that antidepressant 
      administration increases expression of CREB mRNA in CA1 and CA3 pyramidal and 
      dentate gyrus granule cell layers of the hippocampus. In addition, levels of CRE 
      immunoreactivity and of CRE binding activity were increased by chronic 
      antidepressant administration, which indicates that expression and function of 
      CREB protein are increased along with its mRNA. Chronic administration of the 
      phosphodiesterase (PDE) inhibitors rolipram or papaverine also increased 
      expression of CREB mRNA in hippocampus, demonstrating a role for the cAMP 
      cascade. Moreover, coadministration of rolipram with imipramine resulted in a 
      more rapid induction of CREB than with either treatment alone. Increased 
      expression and function of CREB suggest that specific target genes may be 
      regulated by these treatments. We have found that levels of brain-derived 
      neurotrophic factor (BDNF) and trkB mRNA are also increased by administration of 
      antidepressants or PDE inhibitors. These findings indicate that upregulation of 
      CREB is a common action of chronic antidepressant treatments that may lead to 
      regulation of specific target genes, such as BDNF and trkB, and to the long-term 
      effects of these treatments on brain function.
FAU - Nibuya, M
AU  - Nibuya M
AD  - Department of Psychiatry, Yale University School of Medicine, New Haven, 
      Connecticut 06508, USA.
FAU - Nestler, E J
AU  - Nestler EJ
FAU - Duman, R S
AU  - Duman RS
LA  - eng
GR  - 2P01 MH25642/MH/NIMH NIH HHS/United States
GR  - MH45481/MH/NIMH NIH HHS/United States
GR  - MH53199/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Phosphodiesterase Inhibitors)
RN  - 0 (Pyrrolidinones)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 01K63SUP8D (Fluoxetine)
RN  - 3E3V44J4Z9 (Tranylcypromine)
RN  - 9753I242R5 (1-Naphthylamine)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - K676NL63N7 (Rolipram)
RN  - OGG85SX4E4 (Imipramine)
RN  - QUC7NX6WMB (Sertraline)
RN  - TG537D343B (Desipramine)
SB  - IM
MH  - 1-Naphthylamine/analogs & derivatives/pharmacology
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Base Sequence
MH  - Blotting, Northern
MH  - Brain-Derived Neurotrophic Factor
MH  - Cyclic AMP Response Element-Binding Protein/*drug effects/genetics
MH  - Desipramine/pharmacology
MH  - Electric Stimulation
MH  - Fluoxetine/pharmacology
MH  - Hippocampus/chemistry/drug effects/*physiology
MH  - Imipramine/pharmacology
MH  - In Situ Hybridization
MH  - Male
MH  - Molecular Sequence Data
MH  - Nerve Growth Factors/drug effects/genetics
MH  - Nerve Tissue Proteins/drug effects/genetics
MH  - Phosphodiesterase Inhibitors/pharmacology
MH  - Pyrrolidinones/pharmacology
MH  - RNA, Messenger/analysis
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor Protein-Tyrosine Kinases/drug effects/genetics
MH  - Receptor, trkB
MH  - Receptors, Nerve Growth Factor/drug effects/genetics
MH  - Rolipram
MH  - Sertraline
MH  - Time Factors
MH  - Tranylcypromine/pharmacology
PMC - PMC6578518
EDAT- 1996/04/01 00:00
MHDA- 1996/04/01 00:01
PMCR- 1996/10/01
CRDT- 1996/04/01 00:00
PHST- 1996/04/01 00:00 [pubmed]
PHST- 1996/04/01 00:01 [medline]
PHST- 1996/04/01 00:00 [entrez]
PHST- 1996/10/01 00:00 [pmc-release]
AID - 10.1523/JNEUROSCI.16-07-02365.1996 [doi]
PST - ppublish
SO  - J Neurosci. 1996 Apr 1;16(7):2365-72. doi: 10.1523/JNEUROSCI.16-07-02365.1996.