PMID- 8603339
OWN - NLM
STAT- MEDLINE
DCOM- 19960516
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 86
IP  - 2
DP  - 1996 Feb
TI  - Derivative (6)t(1;6)(q22;p21) revealed in bone marrow cells by FISH 9 months 
      before diagnosis of acute T-lymphoblastic leukemia.
PG  - 131-5
AB  - A chromosomal clone with unbalanced translocation resulting in partial trisomy of 
      segment 1q22-qter and partial monosomy of segment 6p21-pter was revealed by 
      fluorescence in situ hybridization (FISH) using a panel of different whole 
      chromosome painting probes. The pathologic clone appeared after sequential 
      chemotherapy treatment for AML-M5 when the patient was in complete remission 
      before development of T-ALL. However, this clone was present during the whole 
      period of treatment for T-ALL. The clone remained the only chromosomal aberration 
      found. Breakpoints were detected more easily and more precisely with the use of 
      the FISH technique than with G-banding only.
FAU - Michalova, K
AU  - Michalova K
AD  - 3rd Medical Department, General Faculty Hospital, 1st Medical Faculty of Charles 
      University, Prague, Czech Republic.
FAU - Lemez, P
AU  - Lemez P
FAU - Bartsch, O
AU  - Bartsch O
FAU - Brezinova, J
AU  - Brezinova J
FAU - Zemanova, Z
AU  - Zemanova Z
FAU - Jelinek, J
AU  - Jelinek J
FAU - Horak, I D
AU  - Horak ID
FAU - Burke, P J
AU  - Burke PJ
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Bone Marrow/*pathology
MH  - *Chromosomes, Human, Pair 1
MH  - *Chromosomes, Human, Pair 6
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia-Lymphoma, Adult T-Cell/diagnosis/*genetics/pathology
MH  - Middle Aged
MH  - *Translocation, Genetic
EDAT- 1996/02/01 00:00
MHDA- 1996/02/01 00:01
CRDT- 1996/02/01 00:00
PHST- 1996/02/01 00:00 [pubmed]
PHST- 1996/02/01 00:01 [medline]
PHST- 1996/02/01 00:00 [entrez]
AID - 0165-4608(95)00199-9 [pii]
AID - 10.1016/0165-4608(95)00199-9 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1996 Feb;86(2):131-5. doi: 10.1016/0165-4608(95)00199-9.