PMID- 8603480
OWN - NLM
STAT- MEDLINE
DCOM- 19960516
LR  - 20190512
IS  - 0143-3334 (Print)
IS  - 0143-3334 (Linking)
VI  - 16
IP  - 12
DP  - 1995 Dec
TI  - Carcinogenicity of nitropyrenes in the newborn female rat.
PG  - 3027-30
AB  - The carcinogenicities of 1-nitropyrene (1-NP), 4-nitropyrene (4-NP), 
      1,3-dinitropyrene (1,3-DNP), 1,6-dinitropyrene (1,6-DNP), 1,8-dinitropyrene 
      (1,8-DNP), 3-hydroxy-1-nitropyrene (3-OH-1-NP) and a mixture of 6- and 
      8-hydroxy-1-nitropyrene (6/8-OH-1-NP) were investigated in newborn female rats. 
      Newborn female CD rats were treated s.c. eight times at weekly intervals with a 
      total dose of 6.3 mumol 1-NP,1,3-DNP,1,6-DNP or 1,8-DNP; control animals received 
      only dimethylsulfoxide (DMSO). The experiment was terminated at 67 weeks. With 
      the exception of 1,6-DNP- and 1,8-DNP-treated animals, which had average survival 
      periods of 149 and 164 days respectively, the animals administered the other 
      compounds did not show decreased survival. Malignant fibrous histiocytomas were 
      observed in 12%, 100% and 100% of the rats treated with 1,3-, 1,6- and 1,8-DNP 
      respectively. Leukemia was found in 20% and 22% of the animals treated with 1,6- 
      and 1,8-DNP respectively. No control rats developed these tumors. Additionally, 
      mammary tumors were induced in rats treated with 1-NP. Newborn female CD rats 
      were similarly treated with 1-NP, 4-NP, 3-OH-1-NP, 6/8-OH-1-NP or DMSO and 
      newborn female F344 rats were treated with 1-NP or DMSO. The experiment was 
      terminated at 86 weeks, 1-NP and 4-NP produced mammary adenocarcinoma in CD rats. 
      Although 1-NP did not produce mammary adenocarcinoma in F344 rats, it induced 
      leukemia. 4-NP also induced malignant fibrous histiocytomas in CD rats. This 
      study demonstrates that 4-NP is more carcinogenic than 1-NP and that CD rats are 
      more susceptible than F344 rats to mammary carcinogenesis by 1-NP. Additionally, 
      1,6- and 1,8-DNP are more potent than 1-NP in inducing malignant fibrous 
      histiocytomas and leukemia.
FAU - Imaida, K
AU  - Imaida K
AD  - Department of Chemical Carcinogenesis, Michigan Cancer Foundation, Detroit 48201, 
      USA.
FAU - Lee, M S
AU  - Lee MS
FAU - Land, S J
AU  - Land SJ
FAU - Wang, C Y
AU  - Wang CY
FAU - King, C M
AU  - King CM
LA  - eng
GR  - CA 23386/CA/NCI NIH HHS/United States
GR  - CA 23800/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Carcinogenesis
JT  - Carcinogenesis
JID - 8008055
RN  - 0 (Carcinogens)
RN  - 0 (Pyrenes)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Carcinogenicity Tests
MH  - Carcinogens/*toxicity
MH  - Female
MH  - Histiocytoma, Benign Fibrous/chemically induced
MH  - Leukemia, Experimental/chemically induced
MH  - Mammary Neoplasms, Experimental/chemically induced
MH  - Pregnancy
MH  - Pyrenes/*toxicity
MH  - Rats
EDAT- 1995/12/01 00:00
MHDA- 1995/12/01 00:01
CRDT- 1995/12/01 00:00
PHST- 1995/12/01 00:00 [pubmed]
PHST- 1995/12/01 00:01 [medline]
PHST- 1995/12/01 00:00 [entrez]
AID - 10.1093/carcin/16.12.3027 [doi]
PST - ppublish
SO  - Carcinogenesis. 1995 Dec;16(12):3027-30. doi: 10.1093/carcin/16.12.3027.