PMID- 8603481
OWN - NLM
STAT- MEDLINE
DCOM- 19960516
LR  - 20190512
IS  - 0143-3334 (Print)
IS  - 0143-3334 (Linking)
VI  - 16
IP  - 12
DP  - 1995 Dec
TI  - Human exposure and dosimetry of polycyclic aromatic hydrocarbons in urine from 
      Xuan Wei, China with high lung cancer mortality associated with exposure to 
      unvented coal smoke.
PG  - 3031-6
AB  - The lung cancer mortality rate in Xuan Wei (XW) county, China, is 5-fold the 
      national average of China; the rate for women is the highest in China. Xuan Wei 
      residents have been exposed to unvented coal or wood smoke during cooking or 
      heating in homes. This study investigated indoor air exposure and dosimetry of 
      polycyclic aromatic hydrocarbons (PAHs) in XW residents using smoky coal. Indoor 
      air particles collected during cooking in four XW homes using smoky coal were 
      analyzed for PAHs by GC/MS. Urine samples from 16 XW non-smoking women and six XW 
      smoking men, eight Kunming non-smoking controls and four non-smoking Chinese 
      American controls were analyzed for PAHs and hydroxy-PAHs by GC/MS. The results 
      showed that XW residents were exposed to PAHs at occupational levels. The potent 
      carcinogen, dibenzo[a,l] pyrene (4.9 +/- 1.3 micrograms/m3) was found in the 
      indoor air of the XW homes. The levels of urinary hydroxy-PAH were higher than 
      those of the parent compounds in most subjects, indicating that most PAHs were 
      metabolized. In urine, the mean levels of 9-hydroxy BaP (BaP) and BaP are 1.5 +/- 
      0.5 mumol/mol creatinine and 0.5 +/- 0.3 microns/mol for XW men, 1.9 +/- 0.9 
      microns/mol and 0.5 +/- 0.3 microns/mol for XW women. In general, the levels of 
      PAH metabolites in urine were higher in the XW residents than in Kunming and 
      Chinese American controls; however only the concentrations of 9-hydroxy BaP in XW 
      women showed statistically significant difference from the Kunming controls (P < 
      0.05 by ranking test). The mean levels of 3 methylated-PAHs analyzed were 
      4.8-fold higher than that of the parent PAHs in XW subjects. This is consistent 
      with previous findings that alkylated PAHs are the major mutagens in the XW 
      indoor air and may be etiologically important in XW lung cancer.
FAU - Mumford, J L
AU  - Mumford JL
AD  - US EPA, Research Triangle Park, NC 27711, USA.
FAU - Li, X
AU  - Li X
FAU - Hu, F
AU  - Hu F
FAU - Lu, X B
AU  - Lu XB
FAU - Chuang, J C
AU  - Chuang JC
LA  - eng
PT  - Journal Article
PL  - England
TA  - Carcinogenesis
JT  - Carcinogenesis
JID - 8008055
RN  - 0 (Biomarkers)
RN  - 0 (Coal)
RN  - 0 (Polycyclic Compounds)
RN  - 0 (Smoke)
RN  - K5161X06LL (Cotinine)
SB  - IM
MH  - Air Pollution, Indoor
MH  - Biomarkers
MH  - China/epidemiology
MH  - *Coal
MH  - Cotinine/urine
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/*chemically induced/epidemiology/mortality/urine
MH  - Male
MH  - Polycyclic Compounds/*toxicity/urine
MH  - *Smoke
EDAT- 1995/12/01 00:00
MHDA- 1995/12/01 00:01
CRDT- 1995/12/01 00:00
PHST- 1995/12/01 00:00 [pubmed]
PHST- 1995/12/01 00:01 [medline]
PHST- 1995/12/01 00:00 [entrez]
AID - 10.1093/carcin/16.12.3031 [doi]
PST - ppublish
SO  - Carcinogenesis. 1995 Dec;16(12):3031-6. doi: 10.1093/carcin/16.12.3031.