PMID- 8603626
OWN - NLM
STAT- MEDLINE
DCOM- 19960510
LR  - 20190813
IS  - 0013-9580 (Print)
IS  - 0013-9580 (Linking)
VI  - 37
IP  - 1
DP  - 1996 Jan
TI  - Regional increases in brain-derived neurotrophic factor and nerve growth factor 
      mRNAs during amygdaloid kindling, but not in acidic and basist growth factor 
      mRNAs.
PG  - 6-14
AB  - We studied mRNA levels for neurotrophic factors using the amygdaloid k indling 
      model of epilepsy. One hour after stage 5 kindled seizures, there were four-to 
      fivefold increases in brain-derived neurotrophic factor (BDNF) mRNA in rat 
      dentate gyrus and perirhinal cortex. Nerve growth factor (NGF) mRNA levels were 
      increased bilaterally in some (but not all) limbic areas. There were no 
      detectable changes in acidic fibroblast GF (aFGF) mRNA or basic fibroblast GF 
      (bFGF) mRNA for 24 h after the kindled seizures. During kindling, levels of BDNF 
      mRNA in the dentate gyrus correlated with projection to generalized seizures, 
      whereas NGF mRNA in the limbic regions continued to increase during seizure 
      development. These results indicate that the induction of mRNAs for neurotrophic 
      factors, especially for BDNF mRNA in the dentate gyrus, corresponds to the 
      increases in metabolic and electrical ictal discharge associated with kindled 
      seizures. The persistent increase observed in NGF mRNA may be related to enhanced 
      synaptic efficacy during kindling, but aFGF and bFGF are presumed to have little 
      relation to the kindling process.
FAU - Sato, K
AU  - Sato K
AD  - Department of Neuropsychiatry, National Sanatorium Minamiokayama Hospital, Japan.
FAU - Kashihara, K
AU  - Kashihara K
FAU - Morimoto, K
AU  - Morimoto K
FAU - Hayabara, T
AU  - Hayabara T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Epilepsia
JT  - Epilepsia
JID - 2983306R
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (RNA, Messenger)
RN  - 103107-01-3 (Fibroblast Growth Factor 2)
RN  - 104781-85-3 (Fibroblast Growth Factor 1)
SB  - IM
MH  - Amygdala/chemistry/*metabolism
MH  - Animals
MH  - Base Sequence
MH  - Brain/*metabolism
MH  - Brain Chemistry
MH  - Brain-Derived Neurotrophic Factor
MH  - Fibroblast Growth Factor 1/*analysis/biosynthesis
MH  - Fibroblast Growth Factor 2/*analysis/biosynthesis
MH  - Hippocampus/chemistry/metabolism
MH  - In Situ Hybridization
MH  - Kindling, Neurologic/*metabolism
MH  - Male
MH  - Molecular Sequence Data
MH  - Nerve Growth Factors/*analysis/biosynthesis
MH  - Nerve Tissue Proteins/*analysis/biosynthesis
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tissue Distribution
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.1111/j.1528-1157.1996.tb00504.x [doi]
PST - ppublish
SO  - Epilepsia. 1996 Jan;37(1):6-14. doi: 10.1111/j.1528-1157.1996.tb00504.x.