PMID- 8603988
OWN - NLM
STAT- MEDLINE
DCOM- 19960515
LR  - 20190516
IS  - 0741-5400 (Print)
IS  - 0741-5400 (Linking)
VI  - 59
IP  - 2
DP  - 1996 Feb
TI  - Dendritic cells and the replication of HIV-1.
PG  - 158-71
AB  - Dendritic cells (DCs) are a distinct lineage of white cells that arise from CD34+ 
      progenitors in the bone marrow. DCs exhibit many specializations that lead to 
      efficient antigen capture and presentation to T cells, both CD4+ helpers and CD8+ 
      killers. In several human tissues, DCs express the CD4 receptor for HIV-1. Some 
      early reports described the explosive infection of blood-derived DCs by HIV-1 and 
      a severe compromise of their presenting function. In contrast, other studies 
      described active HIV-1 replication when DCs were interacting with CD4+ T cells. 
      This productive infection could begin with a low viral burden in DCs but required 
      that the DCs retain their normal binding and stimulatory function for T cells. In 
      this review we first summarize those features of the DC system that seem 
      pertinent to HIV-1 infection. Then we consider the current literature on the 
      interaction of HIV-1 with DCs, from several different tissues, in HIV-1-infected 
      patients or following challenge with HIV-1 in vitro. The literature leads to the 
      hypothesis that HIV-1 infection is a battleground in which DCs could be leading 
      both of the armies, the aggressor that promotes HIV-1 replication from relatively 
      small numbers of infected cells and the defender that mediates T cell-dependent 
      resistance.
FAU - Cameron, P
AU  - Cameron P
AD  - Laboratory of Cellular Physiology and Immunology, Rockefeller University, New 
      York, USA.
FAU - Pope, M
AU  - Pope M
FAU - Granelli-Piperno, A
AU  - Granelli-Piperno A
FAU - Steinman, R M
AU  - Steinman RM
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Leukoc Biol
JT  - Journal of leukocyte biology
JID - 8405628
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*immunology
MH  - HIV Infections/*immunology/pathology
MH  - HIV-1/*physiology
MH  - Humans
MH  - Virus Replication/*physiology
RF  - 194
EDAT- 1996/02/01 00:00
MHDA- 1996/02/01 00:01
CRDT- 1996/02/01 00:00
PHST- 1996/02/01 00:00 [pubmed]
PHST- 1996/02/01 00:01 [medline]
PHST- 1996/02/01 00:00 [entrez]
AID - 10.1002/jlb.59.2.158 [doi]
PST - ppublish
SO  - J Leukoc Biol. 1996 Feb;59(2):158-71. doi: 10.1002/jlb.59.2.158.