PMID- 8604149
OWN - NLM
STAT- MEDLINE
DCOM- 19960516
LR  - 20131121
IS  - 0098-4108 (Print)
IS  - 0098-4108 (Linking)
VI  - 47
IP  - 3
DP  - 1996 Feb 23
TI  - Developmental toxicity of sarin in rats and rabbits.
PG  - 249-65
AB  - Sarin (Agent GB, isopropyl methylphosphonofluoridate) is an organophosphate 
      cholinesterase inhibitor. Sarin (Type I or Type II) was administered by gavage to 
      CD rats on d 6-15 of gestation at dose levels of 0, 100, 240, or 380 
      micrograms/kg/d and to New Zealand White (NZW) rabbits on d 6-19 of gestation at 
      dose levels of 0, 5, 10, or 15 micrograms/kg/d. Females were weighed on 
      gestational days (GD) 0, 6-16 for rats and 6-20 for rabbits, and immediately 
      prior to termination (GD 20 for rats and GD 29 for rabbits). All animals were 
      monitored daily for clinical signs of toxicity throughout dosing and until 
      sacrifice. At necropsy, gravid uteri were weighed and examined for the number and 
      status of implants (live, resorbed, or dead). Individual fetal body weight, 
      malformations, and variations (external, visceral, and skeletal) were recorded. 
      Rat and rabbit dams in the high-dose groups exhibited significant signs of 
      maternal toxicity and increased maternal mortality. Examination of gravid uteri 
      revealed no statistical differences among treatment groups in the incidence of 
      resorptions or of dead or malformed fetuses, or in average body weight of live 
      fetuses per litter. These results show no evidence or developmental toxicity in 
      the CD rat or NZW rabbit following exposure to either Type I or Type II sarin 
      during embryonic differentiation and major organogenesis, even at a dose that 
      produced maternal toxicity.
FAU - LaBorde, J B
AU  - LaBorde JB
AD  - Division of Reproductive and Development Toxicology, National Center for 
      Toxicological Research, Jefferson, AR 72079, USA.
FAU - Bates, H K
AU  - Bates HK
FAU - Dacre, J C
AU  - Dacre JC
FAU - Young, J F
AU  - Young JF
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Toxicol Environ Health
JT  - Journal of toxicology and environmental health
JID - 7513622
RN  - 0 (Cholinesterase Inhibitors)
RN  - B4XG72QGFM (Sarin)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Body Weight/drug effects
MH  - Cholinesterase Inhibitors/administration & dosage/*toxicity
MH  - Dose-Response Relationship, Drug
MH  - Embryonic and Fetal Development/*drug effects
MH  - Female
MH  - Fetal Resorption/chemically induced
MH  - Male
MH  - Pregnancy
MH  - Rabbits
MH  - Rats
MH  - Sarin/administration & dosage/*toxicity
MH  - Viscera/drug effects/embryology
EDAT- 1996/02/23 00:00
MHDA- 1996/02/23 00:01
CRDT- 1996/02/23 00:00
PHST- 1996/02/23 00:00 [pubmed]
PHST- 1996/02/23 00:01 [medline]
PHST- 1996/02/23 00:00 [entrez]
AID - 10.1080/009841096161771 [doi]
PST - ppublish
SO  - J Toxicol Environ Health. 1996 Feb 23;47(3):249-65. doi: 10.1080/009841096161771.