PMID- 8605327
OWN - NLM
STAT- MEDLINE
DCOM- 19960517
LR  - 20220408
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 87
IP  - 8
DP  - 1996 Apr 15
TI  - Cytogenetic abnormalities in adult acute lymphoblastic leukemia: correlations 
      with hematologic findings outcome. A Collaborative Study of the Group Francais de 
      Cytogenetique Hematologique.
PG  - 3135-42
AB  - Cytogenetic analyses performed at diagnosis on 443 adult patients with acute 
      lymphoblastic leukemia (ALL) were reviewed by the Groupe Francais de 
      Cytogenetique Hematologique, correlated with hematologic data, and compared with 
      findings for childhood ALL. This study showed that the same recurrent 
      abnormalities as those reported in childhood ALL are found in adults, and it 
      determined their frequencies and distribution according to age. Hyperdiploidy 
      greater than 50 chromosomes with a standard pattern of chromosome gains had a 
      lower frequency (7%) than in children, and was associated with the Philadelphia 
      chromosome (Ph) in 11 of 30 cases. Tetraploidy (2%) and triploidy (3%) were more 
      frequent than that in childhood ALL. Hypodiploidy 30-39 chromosomes (2%), 
      characterized by a specific pattern of chromosome losses, might be related to the 
      triploid group that evoked a duplication of the 30-39 hypodiploidy. Both groups 
      shared similar hematologic features. Ph+ ALL (29%) peaked in the 40- to 
      50-year-old age range (49%) and showed a high frequency of myeloid antigens 
      (24%). ALL with t(1;19) (3%) occurred in young adults (median age, 22 years). In 
      T-cell ALL (T-ALL), frequencies of 14q11 breakpoints (26%) and of 
      t(10;14)(q24;q11) (14%) were higher than those in childhood ALL. New recurrent 
      changes were identified, ie, monosomies 7 present in Ph-ALL (17%) and also in 
      other ALL (8%) and two new recurrent translocations, t(1;11)(p34;pll) in T-ALL 
      and t(1;7)(q11-21;q35-36) in Ph+ ALL. The ploidy groups with a favorable 
      prognostic impact were hyperdiploidy greater than 50 without Ph chromosome 
      (median event-free survival [EFS], 46 months) and tetraploidy (median EFS, 46 
      months). The recurrent abnormalities associated with better response to therapy 
      were also significantly correlated to T-cell lineage. Among them, 
      t(10;14)(q24;q11) (median EFS, 46 months) conferred the best prognostic impact 
      (3-year EFS, 75%). Hypodiploidy 30-39 chromosomes and the related triploidy were 
      associated with poor outcome. All Ph-ALL had short EFS (median EFS, 5 months), 
      and no additional change affected this prognostic impact. Most patients with 
      t(1;19) failed therapy within 1 year. Patients with 11q23 changes not because of 
      t(4;11) had a poor outcome, although they did not present the high-risk factors 
      found in t(4;11).
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
SB  - IM
EIN - Blood 1996 Oct 1;88(7):2818
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aneuploidy
MH  - Bone Marrow/pathology
MH  - *Chromosome Aberrations
MH  - Cohort Studies
MH  - Disease-Free Survival
MH  - Female
MH  - France/epidemiology
MH  - Humans
MH  - Karyotyping
MH  - Male
MH  - Middle Aged
MH  - Philadelphia Chromosome
MH  - Precursor Cell Lymphoblastic 
      Leukemia-Lymphoma/blood/*genetics/mortality/pathology
MH  - Prognosis
MH  - Remission Induction
MH  - Treatment Outcome
EDAT- 1996/04/15 00:00
MHDA- 1996/04/15 00:01
CRDT- 1996/04/15 00:00
PHST- 1996/04/15 00:00 [pubmed]
PHST- 1996/04/15 00:01 [medline]
PHST- 1996/04/15 00:00 [entrez]
AID - S0006-4971(20)64715-2 [pii]
PST - ppublish
SO  - Blood. 1996 Apr 15;87(8):3135-42.