PMID- 8608789
OWN - NLM
STAT- MEDLINE
DCOM- 19960528
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 286
IP  - 3
DP  - 1995 Nov 24
TI  - Tumor necrosis factor-alpha prevents interleukin-1 beta from augmenting 
      capsaicin-induced vasodilatation in the rat skin.
PG  - 273-9
AB  - The effect of tumor necrosis factor-alpha (TNF alpha) and tumor necrosis 
      factor-beta (TNF beta) on the capsaicin-induced increase in cutaneous blood flow 
      was investigated in anaesthetized rats. Skin blood flow was measured by 
      laser-Doppler flowmetry. Intraplantar subcutaneous injections of 5-500 pg TNF 
      alpha and 50-5000 pg TNF beta had no effect on local blood flow, whereas 5000 pg 
      TNF alpha induced a transient hyperaemia. However, neither the pretreatment with 
      TNF alpha (5-5000 pg) nor that with TNF beta (50-5000 pg) enhanced the 
      vasodilatator response to intraplantar capsaicin (0.03 micrograms; 0.1 
      microgram), whereas 50 pg interleukin-1 beta augmented the capsaicin-induced 
      hyperaemia (P < 0.05). This enhancement of the cutaneous hyperaemic response to 
      capsaicin was absent when interleukin-1 beta (50 pg) was co-injected with TNF 
      alpha (500 pg or 5000 pg). The vasodilatation caused by calcitonin gene-related 
      peptide or bradykinin was not altered by 500 pg or 5000 pg TNF alpha. These data 
      indicate that TNFs, in contrast to interleukin-1 beta, do not amplify the 
      hyperaemic response to afferent nerve stimulation with capsaicin but reverse the 
      augmentation mediated by interleukin-1 beta.
FAU - Herbert, M K
AU  - Herbert MK
AD  - Department of Anaesthesiology, University of Wurzburg, Germany.
FAU - Hering, S
AU  - Hering S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Interleukin-1)
RN  - 0 (Lymphotoxin-alpha)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - JHB2QIZ69Z (Calcitonin Gene-Related Peptide)
RN  - S07O44R1ZM (Capsaicin)
RN  - S8TIM42R2W (Bradykinin)
SB  - IM
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Bradykinin/pharmacology
MH  - Calcitonin Gene-Related Peptide/pharmacology
MH  - Capsaicin/*pharmacology
MH  - Female
MH  - Hyperemia/chemically induced
MH  - Interleukin-1/*pharmacology
MH  - Lymphotoxin-alpha/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Skin/*blood supply
MH  - Tumor Necrosis Factor-alpha/*pharmacology
MH  - Vasodilation/*drug effects
EDAT- 1995/11/24 00:00
MHDA- 1995/11/24 00:01
CRDT- 1995/11/24 00:00
PHST- 1995/11/24 00:00 [pubmed]
PHST- 1995/11/24 00:01 [medline]
PHST- 1995/11/24 00:00 [entrez]
AID - 0014299995004560 [pii]
AID - 10.1016/0014-2999(95)00456-0 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1995 Nov 24;286(3):273-9. doi: 10.1016/0014-2999(95)00456-0.