PMID- 8608885
OWN - NLM
STAT- MEDLINE
DCOM- 19960530
LR  - 20190707
IS  - 0016-5085 (Print)
IS  - 0016-5085 (Linking)
VI  - 110
IP  - 3
DP  - 1996 Mar
TI  - Localization of neurotrophins and their high-affinity receptors during human 
      enteric nervous system development.
PG  - 756-67
AB  - BACKGROUND & AIMS: Interactions of neurotrophins with the appropriate trk 
      receptors result in growth and maturational alterations in nervous system cells 
      during development. The aim of this study was to examine whether similar 
      interactions could be involved in human enteric nervous system (ENS) survival or 
      differentiation as well. METHODS: Immunocytochemical detection of TrkA, TrkB, and 
      TrkC, as well as the ligands neurotrophin 3 (NT-3) and brain-derived neurotrophic 
      factor (BDNF), was accomplished on normal human fetal and postnatal intestine. 
      RESULTS: Neither neurotrophins nor their receptors were identified in immature 
      postmigrational ENS progenitors at 7 weeks' fetal developmental age; however, 
      TrkC and TrkA were specifically localized to developing ENS cells after 19 
      developmental weeks. From infancy through adulthood, TrkA and TrkB 
      immunoreactivities were localized to both enteric ganglion cells and glia, 
      whereas TrkC was localized exclusively to enteric ganglion cells. In postnatal 
      intestine, BDNF immunoreactivity was primarily localized to enteric ganglion 
      cells, with NT-3 localized to enteric plexuses, intermuscular basal lamina, and 
      along or between circular and longitudinal smooth muscle cells. CONCLUSIONS: 
      These data indicate that neurotrophic influences may be involved in ENS 
      development and survival, with potential importance in functional differentiation 
      disorders of the intestinal ENS.
FAU - Hoehner, J C
AU  - Hoehner JC
AD  - Department of Pediatric Surgery, Uppsala University Hospital, Sweden.
FAU - Wester, T
AU  - Wester T
FAU - Pahlman, S
AU  - Pahlman S
FAU - Olsen, L
AU  - Olsen L
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Gastroenterology
JT  - Gastroenterology
JID - 0374630
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neurotrophin 3)
RN  - 0 (Receptor, Ciliary Neurotrophic Factor)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptor, trkA)
RN  - EC 2.7.10.1 (Receptor, trkC)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brain-Derived Neurotrophic Factor
MH  - Child
MH  - Child, Preschool
MH  - Enteric Nervous System/embryology/*growth & development/metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Infant
MH  - Intestines/innervation
MH  - Middle Aged
MH  - Nerve Growth Factors/*metabolism
MH  - Nerve Tissue Proteins/metabolism
MH  - Neurotrophin 3
MH  - Receptor Protein-Tyrosine Kinases/metabolism
MH  - Receptor, Ciliary Neurotrophic Factor
MH  - Receptor, trkA/metabolism
MH  - Receptor, trkC
MH  - Receptors, Nerve Growth Factor/*metabolism
EDAT- 1996/03/01 00:00
MHDA- 1996/03/01 00:01
CRDT- 1996/03/01 00:00
PHST- 1996/03/01 00:00 [pubmed]
PHST- 1996/03/01 00:01 [medline]
PHST- 1996/03/01 00:00 [entrez]
AID - S0016508596001205 [pii]
AID - 10.1053/gast.1996.v110.pm8608885 [doi]
PST - ppublish
SO  - Gastroenterology. 1996 Mar;110(3):756-67. doi: 10.1053/gast.1996.v110.pm8608885.