PMID- 8609044
OWN - NLM
STAT- MEDLINE
DCOM- 19960529
LR  - 20190512
IS  - 0910-5050 (Print)
IS  - 1876-4673 (Electronic)
IS  - 0910-5050 (Linking)
VI  - 87
IP  - 1
DP  - 1996 Jan
TI  - Hepatocellular carcinoma induction in LEC rats by a low dose of 
      2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.
PG  - 25-9
AB  - A food-borne heterocyclic amine, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline 
      (MeIQx), induces hepatocellular carcinomas (HCCs) in F344 male rats at an 
      incidence of 95%, when fed in the diet at 400 ppm for 61 weeks. In this study, 
      the effect of a low dose of MeIQx was examined in Long-Evans with cinnamon-like 
      coat color (LEC) rats, which have a mutation in Atp7b and suffer from hereditary 
      hepatitis and HCCs, with high levels of copper accumulation in the liver. Rats of 
      the LEC and Long-Evans with agouti coat color (LEA) sibling lines were given a 
      diet containing 40 ppm MeIQx from the age of 23 weeks to 63 weeks, for a total 
      administration period of 40 weeks. In LEC rats, HCCs were observed in 8/8 animals 
      administered MeIQx, and 2/8 rats receiving a normal diet. The number of HCCs per 
      rat (mean +/- SD) was 2.8 +/- 2.0 and 0.3 +/- 0.5, respectively. In the LEA rats, 
      however, no tumors were induced by administration of MeIQx. These results 
      indicate that damaged liver associated with compensatory cell proliferation is 
      much more susceptible to chemical hepatocarcinogens, including MeIQx, than the 
      normal liver.
FAU - Sone, H
AU  - Sone H
AD  - Carcinogenesis Division, National Cancer Research Institute, Tokyo.
FAU - Wakabayashi, K
AU  - Wakabayashi K
FAU - Kushida, H
AU  - Kushida H
FAU - Enomoto, K
AU  - Enomoto K
FAU - Mori, M
AU  - Mori M
FAU - Takeichi, N
AU  - Takeichi N
FAU - Tsuda, H
AU  - Tsuda H
FAU - Sugimura, T
AU  - Sugimura T
FAU - Nagao, M
AU  - Nagao M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Jpn J Cancer Res
JT  - Japanese journal of cancer research : Gann
JID - 8509412
RN  - 0 (Carcinogens)
RN  - 0 (Quinoxalines)
RN  - 77500-04-0 (2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline)
RN  - 789U1901C5 (Copper)
RN  - EC 2.6.1.2 (Alanine Transaminase)
SB  - IM
MH  - Alanine Transaminase/blood
MH  - Animals
MH  - Body Weight/drug effects
MH  - Carcinogens/*toxicity
MH  - Copper/blood/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Liver/anatomy & histology/drug effects
MH  - Liver Neoplasms, Experimental/*chemically induced/metabolism/pathology
MH  - Male
MH  - Organ Size/drug effects
MH  - Quinoxalines/*toxicity
MH  - Rats
MH  - Rats, Inbred Strains
PMC - PMC5920977
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
PMCR- 1996/01/01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
PHST- 1996/01/01 00:00 [pmc-release]
AID - 0910505096845662 [pii]
AID - CAE25 [pii]
AID - 10.1111/j.1349-7006.1996.tb00195.x [doi]
PST - ppublish
SO  - Jpn J Cancer Res. 1996 Jan;87(1):25-9. doi: 10.1111/j.1349-7006.1996.tb00195.x.