PMID- 8611454
OWN - NLM
STAT- MEDLINE
DCOM- 19960531
LR  - 20190705
IS  - 0007-1048 (Print)
IS  - 0007-1048 (Linking)
VI  - 93
IP  - 1
DP  - 1996 Apr
TI  - Detection of donor cell derived acute myelogenous leukaemia in a patient 
      transplanted for chronic myelogenous leukaemia using fluorescence in situ 
      hybridization.
PG  - 163-5
AB  - The recurrence of leukaemia following allogeneic bone marrow transplantation 
      appears to develop rarely in donor cells. However, the standard method for 
      assigning the origin of recurrence, metaphase analysis, can be unreliable. We 
      have applied the technique of fluorescence in situ hybridization (FISH) directly 
      on archival Wright stained bone marrow slides obtained from a patient who 
      developed acute myelogenous leukaemia (AML) following allogeneic bone marrow 
      transplantation (BMT) for chronic myelogenous leukaemia (CML). Using a 
      chromosome-specific DNA probe we linked a chromosomal aberration, previously 
      detected by conventional metaphase analysis, directly to morphologically 
      identifiable blast cells. In this way we were able to assess cell-lineage 
      involvement of the secondary leukaemia and assign a donor origin.
FAU - Lowsky, R
AU  - Lowsky R
AD  - Department of Medicine, Princess Margaret Hospital, Toronto, Canada.
FAU - Fyles, G
AU  - Fyles G
FAU - Minden, M
AU  - Minden M
FAU - Lipton, J
AU  - Lipton J
FAU - Meharchand, J
AU  - Meharchand J
FAU - Tejpar, I
AU  - Tejpar I
FAU - Zipursky, A
AU  - Zipursky A
FAU - Messner, H
AU  - Messner H
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
SB  - IM
MH  - Adult
MH  - *Bone Marrow Transplantation
MH  - Cell Lineage
MH  - Chromosome Deletion
MH  - Chromosomes, Human, Pair 7
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/complications/genetics/*therapy
MH  - Leukemia, Myeloid, Acute/*complications
MH  - Male
MH  - *Tissue Donors
MH  - Transplantation, Homologous
EDAT- 1996/04/01 00:00
MHDA- 1996/04/01 00:01
CRDT- 1996/04/01 00:00
PHST- 1996/04/01 00:00 [pubmed]
PHST- 1996/04/01 00:01 [medline]
PHST- 1996/04/01 00:00 [entrez]
AID - 10.1046/j.1365-2141.1996.454991.x [doi]
PST - ppublish
SO  - Br J Haematol. 1996 Apr;93(1):163-5. doi: 10.1046/j.1365-2141.1996.454991.x.