PMID- 8611468
OWN - NLM
STAT- MEDLINE
DCOM- 19960531
LR  - 20190705
IS  - 0007-1048 (Print)
IS  - 0007-1048 (Linking)
VI  - 93
IP  - 1
DP  - 1996 Apr
TI  - Trisomy 3 in marginal zone B-cell lymphoma: a study based on cytogenetic analysis 
      and fluorescence in situ hybridization.
PG  - 242-9
AB  - Trisomy 3 represents the most frequent and consistent chromosomal abnormality 
      characterizing the recently defined entity marginal zone B-cell lymphoma (MZBCL). 
      By cytogenetic analysis and/or fluorescence in situ hybridization (FISH) on 
      interphase nuclei we found in increased copy number of chromosome 3 in 22/36 
      (61%) successfully analysed cases, including 8/12 cases with extranodal MZBCL, 
      8/13 cases with nodal MZBCL, and 6/11 patients with splenic MZBCL. Sensitivity of 
      interphase cytogenetics was somewhat higher than that of conventional cytogenetic 
      investigation. Structural chromosomal changes involving at least one chromosome 3 
      were seen in 11/20 cases with an increased copy number of chromosome 3: 
      +de(3)(p13) was demonstrated in three cases, and was the sole chromosomal 
      abnormality in one of them; +i(3)(q10) was seen in two other patients; and 
      rearrangements involving various breakpoints on the long arm of chromosome 3 were 
      found in the remaining cases. FISH on metaphase spreads confirmed these 
      structural abnormalities and additionally showed two unexpected translocations 
      involving chromosome 3. We conclude that: (1) trisomy 3 occurs in a high 
      proportion of extranodal, nodal and splenic MZBCL; (2) FISH on interphase nuclei 
      is an additional and sensitive tool in detecting an increased copy number of 
      chromosome 3 in MZBCL; (3) additional structural abnormalities involving the long 
      arm of chromosome 3 are frequent but non-recurrent and are perhaps secondary 
      changes; and (4) abnormalities such as +del(3)(pl3) and +i(3)(q10) suggest that 
      genes located on the long arm of chromosome 3 are of particular importance in the 
      pathogenesis of MZBCL.
FAU - Dierlamm, J
AU  - Dierlamm J
AD  - Department of Pathology, University of Leuven, Belgium.
FAU - Michaux, L
AU  - Michaux L
FAU - Wlodarska, I
AU  - Wlodarska I
FAU - Pittaluga, S
AU  - Pittaluga S
FAU - Zeller, W
AU  - Zeller W
FAU - Stul, M
AU  - Stul M
FAU - Criel, A
AU  - Criel A
FAU - Thomas, J
AU  - Thomas J
FAU - Boogaerts, M
AU  - Boogaerts M
FAU - Delaere, P
AU  - Delaere P
FAU - Cassiman, J J
AU  - Cassiman JJ
FAU - de Wolf-Peeters, C
AU  - de Wolf-Peeters C
FAU - Mecucci, C
AU  - Mecucci C
FAU - Van den Berghe, H
AU  - Van den Berghe H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Chromosomes, Human, Pair 3
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Interphase
MH  - Karyotyping
MH  - Lymphoma, B-Cell/*genetics
MH  - Male
MH  - Metaphase
MH  - Middle Aged
MH  - *Trisomy
EDAT- 1996/04/01 00:00
MHDA- 1996/04/01 00:01
CRDT- 1996/04/01 00:00
PHST- 1996/04/01 00:00 [pubmed]
PHST- 1996/04/01 00:01 [medline]
PHST- 1996/04/01 00:00 [entrez]
AID - 10.1046/j.1365-2141.1996.522522.x [doi]
PST - ppublish
SO  - Br J Haematol. 1996 Apr;93(1):242-9. doi: 10.1046/j.1365-2141.1996.522522.x.