PMID- 8613761
OWN - NLM
STAT- MEDLINE
DCOM- 19960606
LR  - 20231213
IS  - 0270-6474 (Print)
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Linking)
VI  - 15
IP  - 12
DP  - 1995 Dec
TI  - Connexin32 is a myelin-related protein in the PNS and CNS.
PG  - 8281-94
AB  - We have examined the expression of a gap junction protein, connexin32 (Cx32), in 
      Schwann cells and oligodendrocytes. In peripheral nerve, Cx32 is found in the 
      paranodal myelin loops and Schmidt-Lanterman incisures of myelinating Schwann 
      cells, and the levels of Cx32 protein and mRNA change in parallel with those of 
      other myelin-related genes during development, Wallerian degeneration, and axonal 
      regeneration. In the central nervous system, Cx32 is found in oligodendrocytes 
      and their processes, but not in compact myelin, and the levels of Cx32 protein 
      and mRNA increase during development in parallel with those of the other myelin 
      genes. Thus, Cx32 is expressed as part of the myelinating phenotype of both 
      Schwann cells and oligodendrocytes, indicating that this gap junction protein 
      plays in important role in the biology of myelin-forming cells.
FAU - Scherer, S S
AU  - Scherer SS
AD  - Department of Neurology, University of Pennsylvania, Philadelphia 19104-6146, 
      USA.
FAU - Deschenes, S M
AU  - Deschenes SM
FAU - Xu, Y T
AU  - Xu YT
FAU - Grinspan, J B
AU  - Grinspan JB
FAU - Fischbeck, K H
AU  - Fischbeck KH
FAU - Paul, D L
AU  - Paul DL
LA  - eng
GR  - NS01565/NS/NINDS NIH HHS/United States
GR  - NS08075/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Connexins)
RN  - 0 (Myelin Proteins)
RN  - 0 (RNA, Messenger)
RN  - 1F7A44V6OU (Colforsin)
SB  - IM
MH  - Animals
MH  - Axons/physiology
MH  - Cell Communication
MH  - Central Nervous System/*metabolism
MH  - Colforsin/pharmacology
MH  - Connexins/genetics/*metabolism
MH  - Myelin Proteins/genetics/*metabolism
MH  - Myelin Sheath/physiology
MH  - Oligodendroglia/metabolism
MH  - Peripheral Nerves/*metabolism
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Schwann Cells/metabolism/physiology
MH  - Gap Junction beta-1 Protein
PMC - PMC6577923
EDAT- 1995/12/01 00:00
MHDA- 1995/12/01 00:01
PMCR- 1996/06/01
CRDT- 1995/12/01 00:00
PHST- 1995/12/01 00:00 [pubmed]
PHST- 1995/12/01 00:01 [medline]
PHST- 1995/12/01 00:00 [entrez]
PHST- 1996/06/01 00:00 [pmc-release]
AID - 10.1523/JNEUROSCI.15-12-08281.1995 [doi]
PST - ppublish
SO  - J Neurosci. 1995 Dec;15(12):8281-94. doi: 10.1523/JNEUROSCI.15-12-08281.1995.