PMID- 8614802
OWN - NLM
STAT- MEDLINE
DCOM- 19960605
LR  - 20220310
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 272
IP  - 5261
DP  - 1996 Apr 26
TI  - Selective activation of NF-kappa B by nerve growth factor through the 
      neurotrophin receptor p75.
PG  - 542-5
AB  - Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and 
      neurotrophin-3 (NT-3) selectively bind to distinct members of the Trk family of 
      tyrosine kinase receptors, but all three bind with similar affinities to the 
      neurotrophin receptor p75 (p75NTR). The biological significance of neurotrophin 
      binding to p75NTR in cells that also express Trk receptors has been difficult to 
      ascertain. In the absence of TrkA, NGF binding to p75NGR activated the 
      transcription factor nuclear factor kappa B (NF-kappa B) in rat Schwann cells. 
      This activation was not observed in Schwann cells isolated from mice that lacked 
      p75NTR. The effect was selective for NGF; NF-kappa B was not activated by BDNF or 
      NT-3.
FAU - Carter, B D
AU  - Carter BD
AD  - Department of Neurobiochemistry, Max-Planck Institute for Psychiatry, 
      Martinsried, Germany.
FAU - Kaltschmidt, C
AU  - Kaltschmidt C
FAU - Kaltschmidt, B
AU  - Kaltschmidt B
FAU - Offenhauser, N
AU  - Offenhauser N
FAU - Bohm-Matthaei, R
AU  - Bohm-Matthaei R
FAU - Baeuerle, P A
AU  - Baeuerle PA
FAU - Barde, Y A
AU  - Barde YA
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (NF-kappa B)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neurotrophin 3)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Receptor, Nerve Growth Factor)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 9007-49-2 (DNA)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptor, trkA)
SB  - IM
CON - Science. 1996 Apr 26;272(5261):506-7. PMID: 8614797
MH  - Animals
MH  - Base Sequence
MH  - Brain-Derived Neurotrophic Factor
MH  - Cell Nucleus/metabolism
MH  - Cells, Cultured
MH  - DNA/metabolism
MH  - L Cells
MH  - Mice
MH  - Molecular Sequence Data
MH  - NF-kappa B/*metabolism
MH  - Nerve Growth Factors/*metabolism/pharmacology
MH  - Nerve Tissue Proteins/metabolism/pharmacology
MH  - Neurotrophin 3
MH  - Proto-Oncogene Proteins/metabolism
MH  - Rats
MH  - Receptor Protein-Tyrosine Kinases/metabolism
MH  - Receptor, Nerve Growth Factor
MH  - Receptor, trkA
MH  - Receptors, Nerve Growth Factor/*metabolism
MH  - Schwann Cells/*metabolism
MH  - Signal Transduction/*physiology
EDAT- 1996/04/26 00:00
MHDA- 1996/04/26 00:01
CRDT- 1996/04/26 00:00
PHST- 1996/04/26 00:00 [pubmed]
PHST- 1996/04/26 00:01 [medline]
PHST- 1996/04/26 00:00 [entrez]
AID - 10.1126/science.272.5261.542 [doi]
PST - ppublish
SO  - Science. 1996 Apr 26;272(5261):542-5. doi: 10.1126/science.272.5261.542.