PMID- 8616039
OWN - NLM
STAT- MEDLINE
DCOM- 19960610
LR  - 20211203
IS  - 0007-1048 (Print)
IS  - 0007-1048 (Linking)
VI  - 92
IP  - 3
DP  - 1996 Mar
TI  - Spontaneous remission in a patient with therapy-related myelodysplastic syndrome 
      (t-MDS) with monosomy 7.
PG  - 696-8
AB  - We describe a case of spontaneously reversible refractory anaemia, a subtype of 
      myelodysplastic syndrome (MDS), with monosomy 7 secondary to chronic treatment 
      with azathioprine (AZA) in a young renal transplant recipient. AZA was stopped 
      after that conventional cytogenetics and fluorescence in situ hybridization 
      (FISH) had demonstrated the existence of a monosomy 7 clone, 4 months later, 
      haematological values had considerably improved and the karyotypic examination as 
      well as the FISH analysis were normal. The spontaneous remission of this MDS with 
      monosomy 7, which is usually associated with a particularly poor prognosis, could 
      be due to the recovery of a better immunosurveillance following the withdrawal of 
      AZA.
FAU - Renneboog, B
AU  - Renneboog B
AD  - Hopital Universitaire des Enfants Reine Fabiola, Brussels, Belguim.
FAU - Hansen, V
AU  - Hansen V
FAU - Heimann, P
AU  - Heimann P
FAU - De Mulder, A
AU  - De Mulder A
FAU - Jannsen, F
AU  - Jannsen F
FAU - Ferster, A
AU  - Ferster A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
RN  - MRK240IY2L (Azathioprine)
SB  - IM
MH  - Adult
MH  - Anemia, Refractory/chemically induced/*genetics
MH  - Azathioprine/*adverse effects
MH  - *Chromosomes, Human, Pair 7
MH  - Female
MH  - Humans
MH  - Immunosuppression Therapy/adverse effects
MH  - In Situ Hybridization, Fluorescence
MH  - Kidney Transplantation
MH  - *Monosomy
MH  - Myelodysplastic Syndromes/chemically induced/*genetics
MH  - Neoplasm Regression, Spontaneous
EDAT- 1996/03/01 00:00
MHDA- 1996/03/01 00:01
CRDT- 1996/03/01 00:00
PHST- 1996/03/01 00:00 [pubmed]
PHST- 1996/03/01 00:01 [medline]
PHST- 1996/03/01 00:00 [entrez]
AID - 10.1046/j.1365-2141.1996.00400.x [doi]
PST - ppublish
SO  - Br J Haematol. 1996 Mar;92(3):696-8. doi: 10.1046/j.1365-2141.1996.00400.x.