PMID- 8616554
OWN - NLM
STAT- MEDLINE
DCOM- 19960610
LR  - 20101118
IS  - 1073-449X (Print)
IS  - 1073-449X (Linking)
VI  - 153
IP  - 4 Pt 1
DP  - 1996 Apr
TI  - Allelic association of gene markers on chromosomes 5q and 11q with atopy and 
      bronchial hyperresponsiveness.
PG  - 1280-4
AB  - To investigate genetic factors in asthma and atopy, we sought allelic 
      associations for 12 markers near candidate loci for serum total, immunoglobulin E 
      (IgE), and bronchial hyperresponsiveness (BHR) to inhaled histamine in 131 
      families comprising 685 individuals, selected randomly without regard to atopy or 
      asthma. Nonparametric linkage and association analyses were performed with the 
      Nonparametric Analysis of Lineage and Association (NOPAR) program, and parametric 
      analyses were performed with the Complex Inheritance with Diathesis and Severity 
      (COMDS) program on an ordered polychotomy of ranked scores. On chromosome 11q, 
      allele 168 at the D11S527 locus was significantly associated with BHR (p<0.0003) 
      but not with log IgE. At the D11S534 locus, allele 235 was significantly 
      associated with log IgE (p = 0.007) but not with BHR. Both D11S527 and D11S534 
      were too distant from the gene encoding the high-affinity IgE receptor 
      FcepsilonRIbeta to account for the association. At the interleukin-9 (IL-9) 
      locus, the 118 allele showed significant association with serum total IgE 
      (p<0.003) but not with histamine BHR. Parametric tests are more conservative, 
      perhaps because they demand consistency with mendelian inheritance and tight 
      linkage. These findings provide support for the view that both chromosomes 5 and 
      11 may contain genes relevant to asthma and atopy, a possible candidate being the 
      interleukin-4 (IL-4) gene cluster. Because these associations are extremes in a 
      large number of tests, they require confirmation in other samples.
FAU - Doull, I J
AU  - Doull IJ
AD  - Genetic Epidemiology, University Medicine, University of Southampton, Southampton 
      General Hospital, United Kingdom.
FAU - Lawrence, S
AU  - Lawrence S
FAU - Watson, M
AU  - Watson M
FAU - Begishvili, T
AU  - Begishvili T
FAU - Beasley, R W
AU  - Beasley RW
FAU - Lampe, F
AU  - Lampe F
FAU - Holgate, T
AU  - Holgate T
FAU - Morton, N E
AU  - Morton NE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Respir Crit Care Med
JT  - American journal of respiratory and critical care medicine
JID - 9421642
RN  - 0 (Genetic Markers)
RN  - 0 (Interleukin-9)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Asthma/*genetics/immunology
MH  - Bronchial Hyperreactivity/*genetics/immunology
MH  - Child
MH  - *Chromosomes, Human, Pair 11
MH  - *Chromosomes, Human, Pair 5
MH  - Eczema/genetics/immunology
MH  - *Genetic Linkage
MH  - Genetic Markers
MH  - Humans
MH  - Immunoglobulin E
MH  - Interleukin-9
MH  - Middle Aged
MH  - Rhinitis, Allergic, Seasonal/genetics/immunology
EDAT- 1996/04/01 00:00
MHDA- 1996/04/01 00:01
CRDT- 1996/04/01 00:00
PHST- 1996/04/01 00:00 [pubmed]
PHST- 1996/04/01 00:01 [medline]
PHST- 1996/04/01 00:00 [entrez]
AID - 10.1164/ajrccm.153.4.8616554 [doi]
PST - ppublish
SO  - Am J Respir Crit Care Med. 1996 Apr;153(4 Pt 1):1280-4. doi: 
      10.1164/ajrccm.153.4.8616554.