PMID- 8616557
OWN - NLM
STAT- MEDLINE
DCOM- 19960610
LR  - 20071114
IS  - 1073-449X (Print)
IS  - 1073-449X (Linking)
VI  - 153
IP  - 4 Pt 1
DP  - 1996 Apr
TI  - Primary pulmonary hypertension in HIV infection: an outcome determined by 
      particular HLA class II alleles.
PG  - 1299-301
AB  - Primary pulmonary hypertension (PPH) may have an autoimmune basis that is 
      influenced by host immunogenetics. The pathogenesis of primary pulmonary 
      hypertension in human immunodeficiency virus (HIV) infection is unclear. The 
      objective of this study was to determine whether patients with PPH and HIV 
      infection have distinctive immunogenetic profiles. Ten racially mixed 
      HIV-infected patients with PPH were typed for human leukocyte antigen (HLA) class 
      II (DRB1, 3, 4, 5 and DQB1) by DNA-PCR sequence-specific oligonucleotide probes. 
      Results were compared with two control groups: 128 HIV-negative Caucasians and a 
      previously reported group of 97 HIV-positive, racially mixed control subjects. In 
      those with PPH, there was a significantly increased frequency of HLA-DR6 
      (-DRB1*1301/2 subtypes) and of HLA-DR52 (DRB3*0301 subtype). These findings 
      suggest that HIV-associated PPH reflects a host response to HIV-1 determined by 
      one or more HLA-DR alleles located within the major histocompatibility complex. 
      The same HLA-DR6 subtype found at increased frequency in our patients has 
      previously been associated with the development of a CD8 lymphocytic host 
      response to HIV-1, termed diffuse infiltrative lymphocytosis syndrome (DILS), 
      which resembles autoimmune Sjogren's disease and is associated with prolonged 
      survival. Together, these findings suggest that HIV-positive PPH may represent a 
      clinical outcome that has similarities with that resulting from the 
      immunogenetically determined host response present in DILS.
FAU - Morse, J H
AU  - Morse JH
AD  - Department of Medicine, Columbia University College of Physicians and Surgeons, 
      New York, New York, USA.
FAU - Barst, R J
AU  - Barst RJ
FAU - Itescu, S
AU  - Itescu S
FAU - Flaster, E R
AU  - Flaster ER
FAU - Sinha, G
AU  - Sinha G
FAU - Zhang, Y
AU  - Zhang Y
FAU - Fotino, M
AU  - Fotino M
LA  - eng
GR  - HL-48333/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Respir Crit Care Med
JT  - American journal of respiratory and critical care medicine
JID - 9421642
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Child
MH  - Disease Susceptibility
MH  - Female
MH  - HIV Infections/*complications/genetics/*immunology
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
MH  - Hypertension, Pulmonary/*complications/genetics/*immunology
MH  - Male
MH  - Prognosis
EDAT- 1996/04/01 00:00
MHDA- 1996/04/01 00:01
CRDT- 1996/04/01 00:00
PHST- 1996/04/01 00:00 [pubmed]
PHST- 1996/04/01 00:01 [medline]
PHST- 1996/04/01 00:00 [entrez]
AID - 10.1164/ajrccm.153.4.8616557 [doi]
PST - ppublish
SO  - Am J Respir Crit Care Med. 1996 Apr;153(4 Pt 1):1299-301. doi: 
      10.1164/ajrccm.153.4.8616557.